Document Detail

Efficacy of a pre-thickened infant formula: a multicenter, double-blind, randomized, placebo-controlled parallel group trial in 104 infants with symptomatic gastroesophageal reflux.
MedLine Citation:
PMID:  12921449     Owner:  NLM     Status:  MEDLINE    
To evaluate a pre-thickened formula (Enfamil AR) for regurgitant gastroesophageal reflux, 104 infants were enrolled in a 5-week, multicenter, double-blind, randomized, placebo-controlled parallel group trial. The Enfamil AR group showed greater symptom reduction by the end of the first week: percent feedings with any regurgitation (p = 0.045), total regurgitation volume score (p = 0.035), and percent feedings with choke-gag-cough (p = 0.004). The most symptomatic infants at baseline had a reduction in trouble sleeping significantly with Enfamil AR by the end of the study (p = 0.030). This formula flows through a standard nipple, reduces regurgitation and choking-gagging-coughing within a week, and improves sleep in the most symptomatic babies by 5 weeks, without causing constipation.
Jon A Vanderhoof; J Roberto Moran; Cheryl L Harris; Kimberly L Merkel; Susan R Orenstein
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical pediatrics     Volume:  42     ISSN:  0009-9228     ISO Abbreviation:  Clin Pediatr (Phila)     Publication Date:    2003 Jul-Aug
Date Detail:
Created Date:  2003-08-18     Completed Date:  2003-12-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372606     Medline TA:  Clin Pediatr (Phila)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  483-95     Citation Subset:  AIM; IM    
Joint Section of Pediatric Gastroenterology and Nutrition, University of Nebraska Medical Center and Creighton University, Omaha, Nebraska, USA.
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MeSH Terms
Double-Blind Method
Gastroesophageal Reflux / diet therapy*
Infant Formula*
Infant, Newborn
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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