Document Detail


Efficacy of polyethylene glycol 4000 on constipation of posttraumatic bedridden patients.
MedLine Citation:
PMID:  20515598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the efficacy and safety of polyethylene glycol 4000 on adult patients with functional constipation due to posttraumatic confinement to bed. METHODS: A total of 201 posttraumatic bedridden patients were studied in this prospective, open-labeled, single-group study. Polyethylene glycol 4000 was administered orally for 14 days and the dosage was adjusted according to the Bristol stool types. Demographic characteristics, disease status, treatment period and factors affecting clinical outcome, especially the concomitant medications, were recorded. RESULTS: After administration of polyethylene glycol 4000, 194 cases (96.52%) showed remission of constipation, including 153 (76.12%) persistent remission. The average defecation frequency increased significantly after treatment and the percentage of patients with stools of normal types (Bristol types 3-5) increased as well. Genders, ages and concomitant medications showed no significant influence on the persistent remission rate. After consecutive treatment for two weeks, patients with slight movement showed a significantly higher remission rate than those without movement (95% vs 80%). At the end of treatment, most accompanying symptoms were relieved obviously. Patients with a medical history of constipation or ever taking laxatives showed a lower remission rate. Sixty cases (29.85%) developed diarrhea during the observational period, among whom 6 (10%) withdrew from the clinical observation voluntarily at the first onset of diarrhea. Two cases suffered from abdominal pain. CONCLUSIONS: Polyethylene glycol 4000 has efficacy on functional constipation in posttraumatic bedridden patients. Furthermore, patients with milder symptoms, more movement in bed, and longer duration of treatment but without accompanying symptoms can achieve a higher remission rate.
Authors:
Lian-yang Zhang; Yuan-zhang Yao; Tao Wang; Jun Fei; Yue Shen; Yong-hua Chen; Zhao-wen Zong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese journal of traumatology = Zhonghua chuang shang za zhi / Chinese Medical Association     Volume:  13     ISSN:  1008-1275     ISO Abbreviation:  Chin. J. Traumatol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-02     Completed Date:  2010-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886162     Medline TA:  Chin J Traumatol     Country:  China    
Other Details:
Languages:  eng     Pagination:  182-7     Citation Subset:  IM    
Affiliation:
Trauma Center of PLA, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China. hpzhangly@163.com <hpzhangly@163.com>
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Bed Rest
Constipation / drug therapy*,  etiology
Female
Humans
Male
Middle Aged
Polyethylene Glycols / adverse effects,  therapeutic use*
Prospective Studies
Wounds and Injuries / complications*
Chemical
Reg. No./Substance:
0/Polyethylene Glycols

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