| Efficacy of photodynamic therapy with topical 5-aminolevulinic acid using intense pulsed light for Bowen's disease. | |
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MedLine Citation:
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PMID: 20629828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) is reported to be an effective and safe treatment for superficial non-melanoma skin cancers. We have developed an photodynamic therapy with topical delta-aminolevulinic acid (ALA-PDT) protocol using intense pulsed light (IPL) for treating Bowen's disease (BD). Three patients diagnosed with BD by skin biopsy were recruited in this study. They received IPL treatment after 3 h of occlusive dressing with application of ALA. This protocol was repeated every 2 weeks for a total of five sessions. The treated areas did not show any signs of BD for more than 1 year; therefore, it appeared that the affected areas showed improvement in all the patients. No patients withdrew from the study because of side-effects. ALA-PDT with IPL as a light source is well tolerated by patients and is beneficial for treating BD. |
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Authors:
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Toshio Hasegawa; Yasushi Suga; Yuki Mizuno; Kunitaka Haruna; Hideoki Ogawa; Shigaku Ikeda |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of dermatology Volume: 37 ISSN: 1346-8138 ISO Abbreviation: J. Dermatol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-15 Completed Date: 2010-10-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600545 Medline TA: J Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 623-8 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan. t-hase@juntendo.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged, 80 and over Aminolevulinic Acid / therapeutic use* Bowen's Disease / drug therapy*, pathology Female Humans Photochemotherapy / methods* Photosensitizing Agents / therapeutic use* Skin Neoplasms / drug therapy*, pathology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Photosensitizing Agents; 106-60-5/Aminolevulinic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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