Document Detail


Efficacy of photodynamic therapy with topical 5-aminolevulinic acid using intense pulsed light for Bowen's disease.
MedLine Citation:
PMID:  20629828     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) is reported to be an effective and safe treatment for superficial non-melanoma skin cancers. We have developed an photodynamic therapy with topical delta-aminolevulinic acid (ALA-PDT) protocol using intense pulsed light (IPL) for treating Bowen's disease (BD). Three patients diagnosed with BD by skin biopsy were recruited in this study. They received IPL treatment after 3 h of occlusive dressing with application of ALA. This protocol was repeated every 2 weeks for a total of five sessions. The treated areas did not show any signs of BD for more than 1 year; therefore, it appeared that the affected areas showed improvement in all the patients. No patients withdrew from the study because of side-effects. ALA-PDT with IPL as a light source is well tolerated by patients and is beneficial for treating BD.
Authors:
Toshio Hasegawa; Yasushi Suga; Yuki Mizuno; Kunitaka Haruna; Hideoki Ogawa; Shigaku Ikeda
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of dermatology     Volume:  37     ISSN:  1346-8138     ISO Abbreviation:  J. Dermatol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-15     Completed Date:  2010-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  623-8     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan. t-hase@juntendo.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged, 80 and over
Aminolevulinic Acid / therapeutic use*
Bowen's Disease / drug therapy*,  pathology
Female
Humans
Photochemotherapy / methods*
Photosensitizing Agents / therapeutic use*
Skin Neoplasms / drug therapy*,  pathology
Treatment Outcome
Chemical
Reg. No./Substance:
0/Photosensitizing Agents; 106-60-5/Aminolevulinic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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