| Efficacy of photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 in a rabbit model of chronic myocardial infarction. | |
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MedLine Citation:
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PMID: 15916971 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Therapeutic angiogenesis in ischemic myocardium has been shown to be an effective strategy to improve regional blood flow and myocardial function. However, no effective delivery system for growth factor administration is yet known to induce important therapeutic angiogenic responses in ischemic myocardium. MATERIALS AND METHODS: FGF-2-incorporated chitosan (FGF-2/chitosan) hydrogels were immobilized on the surface of ischemic myocardium of rabbit models of chronic myocardial infarction by UV-irradiation. After 4 weeks, cardiac functional analyses by noradrenalin challenge and histopathological analyses were performed to evaluate the efficacy of a controlled release of FGF-2 from FGF-2/chitosan hydrogel immobilized on the surface of ischemic myocardium. RESULTS: Significant improvement by application of FGF-2/chitosan hydrogels was found in systolic pressure at the left ventricle, +dp/dt maximum, and -dp/dt maximum during noradrenalin challenge at a dose of 1 microg/kg/min. Histological observations showed that a significantly larger amount of viable myocardium and CD 31 immunostained blood vessels were found in the FGF-2/chitosan hydrogel-applied group than only the chitosan-applied and control groups. CONCLUSIONS: These preliminary results indicate that the controlled release of biologically active FGF-2 molecules from FGF-2/chitosan hydrogel induces angiogenesis and possibly collateral circulation in ischemic myocardium, thereby protecting the myocardium. |
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Authors:
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Masanori Fujita; Masayuki Ishihara; Yuji Morimoto; Masafumi Simizu; Yoshio Saito; Hirofumi Yura; Takemi Matsui; Bonpei Takase; Hidemi Hattori; Yasuhiro Kanatani; Makoto Kikuchi; Tadaaki Maehara |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of surgical research Volume: 126 ISSN: 0022-4804 ISO Abbreviation: J. Surg. Res. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-05-26 Completed Date: 2005-07-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: United States |
Other Details:
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Languages: eng Pagination: 27-33 Citation Subset: IM |
Affiliation:
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Department of Medical Engineering, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan. BXB01424@nifty.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chitosan / administration & dosage* Coronary Circulation / drug effects Disease Models, Animal Fibroblast Growth Factor 2 / administration & dosage* Hydrogels / administration & dosage* Male Myocardial Infarction / drug therapy*, pathology, physiopathology Myocardium / pathology Rabbits |
| Chemical | |
Reg. No./Substance:
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0/Hydrogels; 103107-01-3/Fibroblast Growth Factor 2; 9012-76-4/Chitosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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