Document Detail

Efficacy of phenytoin against hyponatremic seizures due to SIADH after administration of anticancer drugs in a neonate.
MedLine Citation:
PMID:  11948390     Owner:  NLM     Status:  MEDLINE    
A neonate with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) developed refractory hyponatremic seizures following administration of anticancer drugs. The seizures did not respond to diazepam, phenobarbital, or lidocaine, but resolved immediately with administration of phenytoin. The low water-excretion capacity in neonates should be taken into consideration when fluid loading is attempted, to avoid renal damage upon administration of drugs such as cisplatin that have a potential damaging effect on the kidney. Phenytoin could be the therapy of choice for SIADH and resulting seizures in the neonatal period.
Miho Okamoto; Yasushi Nako; Atushi Tachibana; Thoru Fujiu; Yasushi Ohki; Takeshi Tomomasa; Akihiro Morikawa
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  22     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:    2002 Apr-May
Date Detail:
Created Date:  2002-04-11     Completed Date:  2002-05-15     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  247-8     Citation Subset:  IM    
Department of Pediatrics, Gunma University School of Medicine, Maebashi, Gunma, Japan.
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MeSH Terms
Anticonvulsants / adverse effects*
Antineoplastic Combined Chemotherapy Protocols / adverse effects*
Hyponatremia / etiology*
Inappropriate ADH Syndrome / chemically induced*,  complications
Infant, Newborn
Orbital Neoplasms / drug therapy*
Phenytoin / adverse effects*
Rhabdomyosarcoma / drug therapy*
Seizures / drug therapy*,  etiology
Reg. No./Substance:
0/Anticonvulsants; 57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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