| Efficacy of pharmacologic glucagon in acute experimental pancreatitis. | |
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MedLine Citation:
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PMID: 3970671 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microcirculatory derangements in the pancreas associated with acute pancreatitis may contribute to a low-flow state and lead to pancreatic necrosis. This study investigated the effects of glucagon, a selective mesenteric arterial dilator, on pancreatic ischemia in canine bile-trypsin-induced pancreatitis (BTP). Measurements of cardiac Index (CI), total pancreatic blood flow (QP), pancreatic oxygen consumption (O2CP), and pancreatic arteriovenous shunt flow (QAVS) were obtained prior to and after inducing BTP. Bile-trypsin-induced pancreatitis was induced in 18 dogs. Nine received lactated Ringer's solution alone (LRPAN) at 6.5 mL/kg/hr, nine received lactated Ringer's solution plus continuous Intravenous (IV) glucagon hydrochloride (GLUPAN) at 1.0 micrograms/kg/min, and nine undergoing periportal dissection without BTP received IV glucagon (GLUCON). Following BTP, CI, QP, and O2CP decreased significantly and QAVS remained unchanged in crystalloid-treated animals (LRPAN). Glucagon administration (GLUPAN) transiently increased CI and QP but failed to improve O2CP and did not change QAVS. The decrease in O2CP observed after BTP in association with a constant QAVS suggests a metabolic block to oxygen uptake at the cellular level. Glucagon in pharmacologic doses does not reverse abnormalities in O2CP and is therefore of questionable physiologic benefit in the treatment of acute pancreatitis. |
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Authors:
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F E Eckhauser; J A Knol; M G Inman; W E Strodel |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of surgery (Chicago, Ill. : 1960) Volume: 120 ISSN: 0004-0010 ISO Abbreviation: Arch Surg Publication Date: 1985 Mar |
Date Detail:
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Created Date: 1985-03-21 Completed Date: 1985-03-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9716528 Medline TA: Arch Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 355-60 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Dogs Female Glucagon / pharmacology*, therapeutic use Hemodynamics / drug effects Isotonic Solutions / pharmacology Male Microcirculation Oxygen Consumption / drug effects Pancreas / blood supply, drug effects*, physiopathology Pancreatitis / drug therapy, physiopathology* Random Allocation Regional Blood Flow / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Isotonic Solutions; 8022-63-7/Ringer's lactate; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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