| Efficacy of peroxisome proliferative activated receptor (PPAR)-alpha ligands, fenofibrate, on intimal hyperplasia and constrictive remodeling after coronary angioplasty in porcine models. | |
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MedLine Citation:
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PMID: 16325819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Constrictive remodeling and intimal hyperplasia play a prominent role in restenosis after angioplasty. It has been reported that the severity of constrictive remodeling and intimal hyperplasia correlate with adventitial angiogenesis and inflammation. Experimental evidence indicates that inflammation participates in angiogenesis, and therefore inhibition of inflammation may impair neovascularization. We tested whether fenofibrate, peroxisome proliferative activated receptors (PPAR)-alpha specific ligand, inhibits the early inflammation, adventitial angiogenesis, constrictive remodeling and intimal hyperplasia after angioplasty using porcine coronary arteries. Fenofibrate was tested in vivo, in 30 coronary arteries of 10 pigs (1g/day, orally) and was compared to placebo. Quantitative intravascular ultrasound and histopathologic assessment showed that fenofibrate increased lumen (6.28 mm(2) versus 5.15 mm(2)), vessel area (7.34 mm(2) versus 6.69 mm(2)) and inhibited constrictive remodeling. Inflammatory cell infiltration was evaluated with scanning electron microscopy 3 days after angioplasty and was significantly decreased in the treated vessels compared to control. Adventitial angiogenesis 3 days after angioplasty was significantly reduced in the injured vessels derived from the fenofibrate treated group compared to placebo. In conclusion, pharmacological activation of PPAR-alpha inhibited constrictive remodeling and neointimal hyperplasia after angioplasty through inhibition of inflammation and adventitial neovascularization. |
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Authors:
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Takatoshi Kasai; Katsumi Miyauchi; Takayuki Yokoyama; Kouichiro Aihara; Hiroyuki Daida |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2005-12-02 |
Journal Detail:
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Title: Atherosclerosis Volume: 188 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-04 Completed Date: 2007-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 274-80 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Juntendo University, School of Medicine, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary
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adverse effects* Animals Coronary Restenosis / drug therapy*, etiology Coronary Vessels / drug effects, surgery*, ultrasonography Hyperplasia / drug therapy*, etiology Immunohistochemistry Ligands Neovascularization, Pathologic / pathology PPAR alpha / metabolism Procetofen / metabolism, pharmacology* Sus scrofa |
| Chemical | |
Reg. No./Substance:
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0/Ligands; 0/PPAR alpha; 49562-28-9/Procetofen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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