| Efficacy of peritoneal oxygenation using a novel artificial oxygen carrier (TRM-645) in a rat respiratory insufficiency model. | |
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MedLine Citation:
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PMID: 20425549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Supplemental oxygenation is essentially important in critically ill patients with potentially reversible pulmonary insufficiency. An extracorporeal membrane oxygenator and percutaneous cardiopulmonary support have been used for these patients. However, these techniques are associated with so many complications that an additional new therapeutic modality is required. The purpose is to investigate if the peritoneal cavity can be used as "extrapulmonary respiration" that is analogous to peritoneal dialysis and utilizes the efficacy of liposome-encapsulated hemoglobin (artificial oxygen carrier; TRM-645). METHODS: Rats weighing an average of 300 g (n = 18) received an incision in the right chest to generate pneumothorax, which resulted in severe and lethal hypoxia. Oxygenated TRM-645 and human red blood cells (MAP group) were administered into the peritoneum in the experimental rats' pneumothorax model. No treatment except the right pneumothorax was administered to the sham group. RESULTS: Survival times from the pneumothorax were significantly longer in the TRM-645 and MAP groups than in the sham group (32.0 +/- 6.9 and 22.0 +/- 4.9 min vs 9.2 +/- 1.9 min, P < 0.01). In addition, an arterial blood gas analysis showed that the oxygenation in levels significantly improved. CONCLUSIONS: The abdomen (peritoneum) can potentially become an "artificial lung" that can be employed in critical care settings. TRM-645 provides an alternative to the use of washed human red blood cells. |
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Authors:
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Noriyuki Matsutani; Bonpei Takase; Yashiro Nogami; Yuichi Ozeki; Shinichi Kaneda; Tadaaki Maehara; Makoto Kikuchi; Masayuki Ishihara |
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Publication Detail:
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Type: Journal Article Date: 2010-04-28 |
Journal Detail:
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Title: Surgery today Volume: 40 ISSN: 1436-2813 ISO Abbreviation: Surg. Today Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-28 Completed Date: 2010-08-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204360 Medline TA: Surg Today Country: Japan |
Other Details:
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Languages: eng Pagination: 451-5 Citation Subset: IM |
Affiliation:
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Department of Surgery II, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Gas Analysis Blood Substitutes / pharmacology* Disease Models, Animal Erythrocyte Transfusion Hemoglobins / pharmacology* Humans Liposomes / pharmacology* Oxygen / metabolism* Peritoneum / metabolism* Pneumothorax, Artificial Random Allocation Rats Rats, Sprague-Dawley Respiratory Insufficiency / physiopathology, therapy* Survival Rate |
| Chemical | |
Reg. No./Substance:
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0/Blood Substitutes; 0/Hemoglobins; 0/Liposomes; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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