| Efficacy of periprosthetic erythromycin delivery for wear debris-induced inflammation and osteolysis. | |
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MedLine Citation:
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PMID: 20607583 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVES: We have reported that oral erythromycin (EM) inhibits periprosthetic tissue inflammation in a group of patients with aseptic loosening. The purpose of this study was to assess the efficacy of local, periprosthetic EM delivery in a rat model. METHODS: Uncoated Ti pins were press-fit into the right tibia of fourteen Sprague-Dawley rats following an intramedullar injection of UHMWPE (ultra high molecular weight polyethylene) particles. Revision surgeries were performed 2 months after the primary surgery. EM was applied to the Peri-Apatite™ (PA) layer of the titanium (Ti) pins. The previously implanted Ti pins were withdrawn and replaced with Ti pins coated either with (n = 7) or without (n = 7) EM. The rats were killed 1 month after "revision surgery". The EM efficacy was evaluated by (MicroCT) μCT and histology. RESULTS: μCT analysis showed that bone volume percentage (BV/TV) was significantly higher in the EM-treated group compared to the untreated group (p < 0.05). Histological analysis showed that EM treatment inhibits UHMWPE particle-induced periprosthetic tissue inflammation compared to the untreated group. CONCLUSION: This study demonstrated that periprosthetic EM delivery reduced periprosthetic inflammation and improved the quality of surrounding bone. |
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Authors:
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Weiping Ren; Renwen Zhang; Monica Hawkins; Tong Shi; David C Markel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-06 |
Journal Detail:
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Title: Inflammation research : official journal of the European Histamine Research Society ... [et al.] Volume: 59 ISSN: 1420-908X ISO Abbreviation: Inflamm. Res. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508160 Medline TA: Inflamm Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 1091-7 Citation Subset: IM |
Affiliation:
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Department of Orthopaedic Surgery, Detroit Medical Center and Providence Hospital Orthopaedic Residency, Detroit, MI, USA. wren@med.wayne.edu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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