Document Detail

Efficacy of periprosthetic erythromycin delivery for wear debris-induced inflammation and osteolysis.
MedLine Citation:
PMID:  20607583     Owner:  NLM     Status:  In-Process    
OBJECTIVES: We have reported that oral erythromycin (EM) inhibits periprosthetic tissue inflammation in a group of patients with aseptic loosening. The purpose of this study was to assess the efficacy of local, periprosthetic EM delivery in a rat model.
METHODS: Uncoated Ti pins were press-fit into the right tibia of fourteen Sprague-Dawley rats following an intramedullar injection of UHMWPE (ultra high molecular weight polyethylene) particles. Revision surgeries were performed 2 months after the primary surgery. EM was applied to the Peri-Apatite™ (PA) layer of the titanium (Ti) pins. The previously implanted Ti pins were withdrawn and replaced with Ti pins coated either with (n = 7) or without (n = 7) EM. The rats were killed 1 month after "revision surgery". The EM efficacy was evaluated by (MicroCT) μCT and histology.
RESULTS: μCT analysis showed that bone volume percentage (BV/TV) was significantly higher in the EM-treated group compared to the untreated group (p < 0.05). Histological analysis showed that EM treatment inhibits UHMWPE particle-induced periprosthetic tissue inflammation compared to the untreated group.
CONCLUSION: This study demonstrated that periprosthetic EM delivery reduced periprosthetic inflammation and improved the quality of surrounding bone.
Weiping Ren; Renwen Zhang; Monica Hawkins; Tong Shi; David C Markel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-06
Journal Detail:
Title:  Inflammation research : official journal of the European Histamine Research Society ... [et al.]     Volume:  59     ISSN:  1420-908X     ISO Abbreviation:  Inflamm. Res.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508160     Medline TA:  Inflamm Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1091-7     Citation Subset:  IM    
Department of Orthopaedic Surgery, Detroit Medical Center and Providence Hospital Orthopaedic Residency, Detroit, MI, USA.
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