| Efficacy of pazufloxacin mesilate in Legionnaires' disease: a case report and in vitro study of the isolate. | |
| | |
MedLine Citation:
|
PMID: 15990982 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We report here a case of culture-proven Legionnaires' disease successfully treated with intravenous injection of pazufloxacin mesilate (PZFX), a fluoroquinolone newly approved in Japan. The patient was a 51-year-old man hospitalized after a diagnosis of community-acquired pneumonia. Legionella pneumophila SG1 was isolated from the patient's bronchoalveolar lavage (BAL) fluid, and the soluble antigen of the bacterium was detected in the fluid as well. Subsequently, intravenous PZFX was administered for a week and proved markedly effective. An in vitro study confirmed that PZFX had excellent extracellular and intracellular activity against the isolate from the patient. This case suggests that PZFX is an option for treating Legionnaires' disease. |
| | |
Authors:
|
Futoshi Higa; Takashi Shinzato; Masato Toyama; Shusaku Haranaga; Makoto Furugen; Masao Tateyama; Kazuyoshi Kawakami; Atsushi Saito |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy Volume: 11 ISSN: 1341-321X ISO Abbreviation: J. Infect. Chemother. Publication Date: 2005 Jun |
Date Detail:
|
Created Date: 2005-07-01 Completed Date: 2005-10-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9608375 Medline TA: J Infect Chemother Country: Japan |
Other Details:
|
Languages: eng Pagination: 164-8 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine and Infectious Diseases, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan. fhiga@med.u-ryukyu.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anti-Bacterial Agents
/
administration & dosage,
therapeutic use* Bronchoalveolar Lavage Fluid / microbiology Fluoroquinolones / administration & dosage, therapeutic use* Humans Injections, Intravenous Legionella pneumophila* Legionnaires' Disease / drug therapy* Male Middle Aged Oxazines / administration & dosage, therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Bacterial Agents; 0/Fluoroquinolones; 0/Oxazines; 127045-41-4/pazufloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A case of necrotizing fasciitis caused by coagulase-negative staphylococcus: utility of magnetic res...
Next Document: Survival factors in the treatment of hereditary retinal degeneration