Document Detail

Efficacy of oral tadalafil, a new long-acting phosphodiesterase-5 inhibitor, for the short-term treatment of pulmonary arterial hypertension in a dog.
MedLine Citation:
PMID:  16533328     Owner:  NLM     Status:  MEDLINE    
Systolic pulmonary arterial hypertension (PAH) was diagnosed in a 15-year-old intact male Yorkshire terrier presented for progressive dyspnoea and coughing. Several examinations were performed (thoracic radiographs, faecal analysis, heartworm antigen test, tracheal fluoroscopy, abdominal ultrasound, complete blood cell count, urine and serum biochemistry) but the PAH remained of unknown origin. Despite medical treatment (diuretics and angiotensin-converting enzyme inhibitor), cardiovascular and respiratory signs dramatically worsened over a 1-month period, with several daily syncope, cyanosis and tachypnoea at rest requiring permanent oxygen therapy. Oral tadalafil (Cialis), a new long-acting phosphodiesterase-5 inhibitor, belonging to the same family as sildenafil (Viagra), was added to the background therapy. The condition of the dog improved quickly (< 24 h), and short-term follow up (7 days) showed a decrease in systolic pulmonary arterial pressure up to 26 mmHg concomitant with the disappearance of all respiratory and cardiac signs of PAH (cyanosis, syncope and tachypnoea). This case is of interest because it concerns the first reported short-term use of tadalafil in canine PAH. However, long-term studies with a large number of diseased animals are now required before prescription by general practitioners could be recommended.
F Serres; A P Nicolle; R Tissier; V Gouni; J-L Pouchelon; V Chetboul
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine     Volume:  53     ISSN:  0931-184X     ISO Abbreviation:  J Vet Med A Physiol Pathol Clin Med     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-14     Completed Date:  2006-07-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100955112     Medline TA:  J Vet Med A Physiol Pathol Clin Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  IM    
Unité pédagogique de Médecine, 7 Avenue du Général de Gaulle, 94 704 Maisons-Alfort Cedex, France.
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MeSH Terms
Carbolines / therapeutic use*
Dog Diseases / drug therapy*
Hypertension, Pulmonary / drug therapy,  veterinary*
Phosphodiesterase Inhibitors / therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Carbolines; 0/Phosphodiesterase Inhibitors; 0/tadalafil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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