Document Detail

Efficacy of ophthalmic viscosurgical devices in maintaining corneal epithelial hydration and clarity: In vitro assessment.
MedLine Citation:
PMID:  23195255     Owner:  NLM     Status:  In-Data-Review    
PURPOSE: To determine the efficacy of hydroxypropyl methylcellulose (HPMC) and hyaluronic acid (HA) in maintaining corneal hydration and optical clarity.
SETTING: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
DESIGN: Experimental study.
METHODS: In porcine autopsy eyes, the effect of 13 ophthalmic viscosurgical devices (OVDs) (5 formulations of HPMC; 8 formulations of HA) in maintaining corneal hydration and optical clarity was tested. The main outcome variables were the time to reach optical clarity of the cornea during dissipation of the OVD and duration of corneal hydration. These variables were assessed after the first application of the OVD, after balanced salt solution application to rehydrate the gel matrix, and after the second application of OVD on top of the first layer.
RESULTS: The study used 57 porcine eyes. High-molecular-weight HA 1.5% (zero shear viscosity [ZSV] 55 122 millipascal seconds [mPa.s]) took a significantly shorter time to reach optical clarity than HA 1.4% (ZSV 36 882 mPa.s) (P=.04). Hyaluronic acid 1.4% and HA 1.5% maintained corneal hydration significantly longer than HPMC 2.0% (P<.001).
CONCLUSIONS: For corneal hydration during short-lasting surgical procedures such as cataract surgery, the results suggest using HPMC because it distributes quickly and provides an adequate duration of sufficient corneal hydration. For corneal hydration during prolonged surgical procedures, such as vitreoretinal surgery, results suggest using HA 1.5% in the formulation because it provides long-lasting corneal hydration.
FINANCIAL DISCLOSURE: Dr. Prinz has a proprietary interest in Croma Pharma GmbH, Leobendorf, Austria. Dr. Findl is a scientific advisor to Croma Pharma GmbH. No other author has a financial or proprietary interest in any material or method mentioned.
Ana Prinz; Carina Fennes; Wolf Buehl; Oliver Findl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cataract and refractive surgery     Volume:  38     ISSN:  1873-4502     ISO Abbreviation:  J Cataract Refract Surg     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8604171     Medline TA:  J Cataract Refract Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2154-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.
From the Departments of Ophthalmology, Hietzing Hospital (Prinz) and Medical University of Vienna (Fennes, Buehl), and the Vienna Institute for Research in Ocular Surgery (Findl), Department of Ophthalmology, Hanusch Hospital, Vienna, Austria.
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