Document Detail

Efficacy of ondansetron and metoclopramide for preventing postoperative emesis following strabismus surgery in children.
MedLine Citation:
PMID:  9165973     Owner:  NLM     Status:  MEDLINE    
A double-blind, randomised, placebo-controlled trial was conducted to compare the efficacy of metoclopramide with the 5-HT3 antagonist, ondansetron, for the prevention of postoperative emesis in children undergoing elective strabismus surgery. None of the children received any premedication and a similar anaesthetic technique was used for all. Ondansetron 0.15, metoclopramide 0.25 or saline placebo were administered following intravenous catheter placement. Episodes of emesis were recorded for the first 24 h for the intervals of 0-2, 2-6 and 6-24 h. The incidence of emesis in the first 24 h was observed to be 71.7% in the placebo group, 34.4% in the ondansetron group (p < 0.001) and 61.4% in the metoclopramide group (p = NS). The severity of vomiting was less in the ondansetron group as compared with metoclopramide (p < 0.01) and placebo (p < 0.001). Recovery room scores were comparable in all the groups. No serious side-effects were observed in the ondansetron group. We conclude that prophylactic ondansetron is effective and superior to metoclopramide in the prevention of postoperative emesis in children following elective strabismus surgery.
D Shende; N G Mandal
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  52     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-06-13     Completed Date:  1997-06-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  496-500     Citation Subset:  AIM; IM    
Dr Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India.
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MeSH Terms
Age Distribution
Antiemetics / therapeutic use*
Child, Preschool
Double-Blind Method
Metoclopramide / therapeutic use
Nausea / prevention & control*
Ondansetron / therapeutic use
Postoperative Complications / prevention & control*
Postoperative Period
Strabismus / surgery*
Vomiting / prevention & control*
Reg. No./Substance:
0/Antiemetics; 364-62-5/Metoclopramide; 99614-02-5/Ondansetron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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