| Efficacy of ondansetron and metoclopramide for preventing postoperative emesis following strabismus surgery in children. | |
| | |
MedLine Citation:
|
PMID: 9165973 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A double-blind, randomised, placebo-controlled trial was conducted to compare the efficacy of metoclopramide with the 5-HT3 antagonist, ondansetron, for the prevention of postoperative emesis in children undergoing elective strabismus surgery. None of the children received any premedication and a similar anaesthetic technique was used for all. Ondansetron 0.15 mg.kg-1, metoclopramide 0.25 mg.kg-1 or saline placebo were administered following intravenous catheter placement. Episodes of emesis were recorded for the first 24 h for the intervals of 0-2, 2-6 and 6-24 h. The incidence of emesis in the first 24 h was observed to be 71.7% in the placebo group, 34.4% in the ondansetron group (p < 0.001) and 61.4% in the metoclopramide group (p = NS). The severity of vomiting was less in the ondansetron group as compared with metoclopramide (p < 0.01) and placebo (p < 0.001). Recovery room scores were comparable in all the groups. No serious side-effects were observed in the ondansetron group. We conclude that prophylactic ondansetron is effective and superior to metoclopramide in the prevention of postoperative emesis in children following elective strabismus surgery. |
| | |
Authors:
|
D Shende; N G Mandal |
Related Documents
:
|
18807643 - Clinical strategies for preventing postoperative nausea and vomitting after middle ear ... 23373043 - Attenuation of cardiovascular responses to direct laryngoscopy and intubation-a compara... 11981193 - Evaluations of the aesthetic results and patient satisfaction with the late pedicled tr... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Anaesthesia Volume: 52 ISSN: 0003-2409 ISO Abbreviation: Anaesthesia Publication Date: 1997 May |
Date Detail:
|
Created Date: 1997-06-13 Completed Date: 1997-06-13 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 496-500 Citation Subset: AIM; IM |
Affiliation:
|
Dr Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Distribution Antiemetics / therapeutic use* Child Child, Preschool Double-Blind Method Female Humans Infant Male Metoclopramide / therapeutic use Nausea / prevention & control* Ondansetron / therapeutic use Postoperative Complications / prevention & control* Postoperative Period Strabismus / surgery* Vomiting / prevention & control* |
| Chemical | |
Reg. No./Substance:
|
0/Antiemetics; 364-62-5/Metoclopramide; 99614-02-5/Ondansetron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Oxygenation of patients undergoing ophthalmic surgery under local anaesthesia.
Next Document: Efficacy of non-steroidal anti-inflammatory drugs for low back pain: a systematic review of randomis...