Document Detail


Efficacy of ondansetron and metoclopramide for preventing postoperative emesis following strabismus surgery in children.
MedLine Citation:
PMID:  9165973     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A double-blind, randomised, placebo-controlled trial was conducted to compare the efficacy of metoclopramide with the 5-HT3 antagonist, ondansetron, for the prevention of postoperative emesis in children undergoing elective strabismus surgery. None of the children received any premedication and a similar anaesthetic technique was used for all. Ondansetron 0.15 mg.kg-1, metoclopramide 0.25 mg.kg-1 or saline placebo were administered following intravenous catheter placement. Episodes of emesis were recorded for the first 24 h for the intervals of 0-2, 2-6 and 6-24 h. The incidence of emesis in the first 24 h was observed to be 71.7% in the placebo group, 34.4% in the ondansetron group (p < 0.001) and 61.4% in the metoclopramide group (p = NS). The severity of vomiting was less in the ondansetron group as compared with metoclopramide (p < 0.01) and placebo (p < 0.001). Recovery room scores were comparable in all the groups. No serious side-effects were observed in the ondansetron group. We conclude that prophylactic ondansetron is effective and superior to metoclopramide in the prevention of postoperative emesis in children following elective strabismus surgery.
Authors:
D Shende; N G Mandal
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  52     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-06-13     Completed Date:  1997-06-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  496-500     Citation Subset:  AIM; IM    
Affiliation:
Dr Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India.
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MeSH Terms
Descriptor/Qualifier:
Age Distribution
Antiemetics / therapeutic use*
Child
Child, Preschool
Double-Blind Method
Female
Humans
Infant
Male
Metoclopramide / therapeutic use
Nausea / prevention & control*
Ondansetron / therapeutic use
Postoperative Complications / prevention & control*
Postoperative Period
Strabismus / surgery*
Vomiting / prevention & control*
Chemical
Reg. No./Substance:
0/Antiemetics; 364-62-5/Metoclopramide; 99614-02-5/Ondansetron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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