Document Detail


Efficacy of nutritional therapy for active Crohn's disease.
MedLine Citation:
PMID:  8563899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the effect of nutritional therapy with an elemental diet (ED) for active Crohn's disease. One hundred and thirty-nine patients with Crohn's disease were enrolled in this study. Remission was judged to be present when the International Organization of Inflammatory Bowel Disease score was < or = 1 and the CRP and ESR values were within the respective normal ranges. An amount of 30kcal per 1kg of ideal body weight (IBW) per day was administered enterally, and the effect on the induction of remission in relation to various patient background factors, such as disease type, history of bowel resection, and the presence/absence of complications, was determined. An excellent remission rate was achieved in those patients to whom an adequate amount of ED could be administered. Remission rates were lower in the patient groups with any of the following complications: stenotic bowel lesions, abdominal masses, fistulas, and anal lesions. Even in those groups in which stenotic lesions or abdominal masses were present, when adequate amounts of ED could be administered, the remission rate did not differ from that in the groups without these complications. The remission rates in the groups with and without fistulas at any site, including fistulas in the anal region, were 40.0% and 82.5%, respectively, with remission being considerably easier to achieve in the patients without fistulas. Similarly, remission was difficult to achieve when anal lesions were present. These results suggest that, for active Crohn's disease, nutritional therapy with ED ( > or = 35kcal/kg IBW) should be enthusiastically administered, and in patients in whom the presence of complications necessitates therapy for 3 months or more, this point be considered to indicate a possible surgical approach.
Authors:
Y Fukuda; T Kosaka; M Okui; H Hirakawa; T Shimoyama
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of gastroenterology     Volume:  30 Suppl 8     ISSN:  0944-1174     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-03-07     Completed Date:  1996-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  83-7     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine 4, Hyogo College of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Crohn Disease / epidemiology,  therapy*
Energy Intake
Enteral Nutrition*
Female
Food, Formulated*
Humans
Male
Remission Induction
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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