Document Detail

Efficacy of a novel topical combination of fipronil, amitraz and (S)-methoprene for treatment and control of induced infestations of brown dog ticks (Rhipicephalus sanguineus) on dogs.
MedLine Citation:
PMID:  21777733     Owner:  NLM     Status:  In-Data-Review    
Four laboratory studies were conducted to demonstrate that a single topical dose of a novel spot-on combination containing fipronil, amitraz and (S)-methoprene (CERTIFECT™, Merial Limited, GA, USA) is efficacious against the brown dog tick, Rhipicephalus sanguineus. In each study, 6-8 male and 6-8 female purpose-bred, laboratory mongrels, terrier cross or Beagles were randomly assigned to one of two study groups (treated and untreated), based on pre-treatment parasite counts. Starting on the day before treatment, each dog was infested weekly with 50 ticks. Ticks were thumb counted at various time points after treatment and weekly infestations starting as early as 6h and continued at 12, 18 and 24h depending on the study. Ticks were removed and counted at 48h after treatment and weekly infestations. CERTIFECT provided rapid and excellent control of pre-existing and newly acquired infestations of R. sanguineus with efficacy as high as 93% within the first 12h after a single topical treatment. Excellent control (>96%) of R. sanguineus as early as 18h, following post treatment infestations was maintained for at least 35 days.
James S Hunter; Derek Baggott; William R Everett; Josephus J Fourie; Luiz G Cramer; Stephen S Yoon; Nadia Collidor; Yasmina Mallouk; Lorne Lee; Jeffrey Blair; Joseph B Prullage
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary parasitology     Volume:  179     ISSN:  1873-2550     ISO Abbreviation:  Vet. Parasitol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7602745     Medline TA:  Vet Parasitol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  318-23     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Merial Limited, Fulton, MO, USA.
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