| Efficacy of a novel topical combination of fipronil, amitraz and (S)-methoprene for treatment and control of induced infestations of brown dog ticks (Rhipicephalus sanguineus) on dogs. | |
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MedLine Citation:
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PMID: 21777733 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Four laboratory studies were conducted to demonstrate that a single topical dose of a novel spot-on combination containing fipronil, amitraz and (S)-methoprene (CERTIFECT™, Merial Limited, GA, USA) is efficacious against the brown dog tick, Rhipicephalus sanguineus. In each study, 6-8 male and 6-8 female purpose-bred, laboratory mongrels, terrier cross or Beagles were randomly assigned to one of two study groups (treated and untreated), based on pre-treatment parasite counts. Starting on the day before treatment, each dog was infested weekly with 50 ticks. Ticks were thumb counted at various time points after treatment and weekly infestations starting as early as 6h and continued at 12, 18 and 24h depending on the study. Ticks were removed and counted at 48h after treatment and weekly infestations. CERTIFECT provided rapid and excellent control of pre-existing and newly acquired infestations of R. sanguineus with efficacy as high as 93% within the first 12h after a single topical treatment. Excellent control (>96%) of R. sanguineus as early as 18h, following post treatment infestations was maintained for at least 35 days. |
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Authors:
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James S Hunter; Derek Baggott; William R Everett; Josephus J Fourie; Luiz G Cramer; Stephen S Yoon; Nadia Collidor; Yasmina Mallouk; Lorne Lee; Jeffrey Blair; Joseph B Prullage |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Veterinary parasitology Volume: 179 ISSN: 1873-2550 ISO Abbreviation: Vet. Parasitol. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7602745 Medline TA: Vet Parasitol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 318-23 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Merial Limited, Fulton, MO, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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