Document Detail

Efficacy of nonpharmacologic interventions in adults with high-normal blood pressure: results from phase 1 of the Trials of Hypertension Prevention. Trials of Hypertension Prevention Collaborative Research Group.
MedLine Citation:
PMID:  9022561     Owner:  NLM     Status:  MEDLINE    
Phase 1 of the Trials of Hypertension Prevention was conducted in 2182 adults, aged 35-54 y, with diastolic blood pressure of 80-89 mm Hg to test the feasibility and blood pressure-lowering effects of seven nonpharmacologic interventions (weight loss, sodium reduction, stress management, and supplementation with calcium, magnesium, potassium, and fish oil). At 6 and 18 mo, weight loss and sodium reduction were well-tolerated and produced significant declines in systolic and diastolic blood pressures (-2.9/-2.4 and -2.1/-1.2 mm Hg for weight loss and sodium reduction, respectively, at 18 mo). None of the other interventions lowered blood pressure significantly at either the 6- or 18-mo follow-up visits. These results suggest that both weight loss and sodium reduction provide an effective means to prevent hypertension. The long-term effects of both of these interventions are being tested in phase 2 of the trial.
P K Whelton; S K Kumanyika; N R Cook; J A Cutler; N O Borhani; C H Hennekens; L H Kuller; H Langford; D W Jones; S Satterfield; N L Lasser; J D Cohen
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  65     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-02-26     Completed Date:  1997-02-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  652S-660S     Citation Subset:  AIM; IM    
Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University School of Hygiene and Public Health, Baltimore, USA.
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MeSH Terms
Blood Pressure
Body Weight
Diet, Sodium-Restricted*
Follow-Up Studies
Hypertension / epidemiology,  prevention & control*
Middle Aged
Patient Compliance
Quality of Life
Risk Factors
Sodium / urine
Sodium, Dietary / administration & dosage
Stress, Physiological / prevention & control
Weight Loss
Reg. No./Substance:
0/Sodium, Dietary; 7440-23-5/Sodium

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