| Efficacy of nonpharmacologic interventions in adults with high-normal blood pressure: results from phase 1 of the Trials of Hypertension Prevention. Trials of Hypertension Prevention Collaborative Research Group. | |
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MedLine Citation:
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PMID: 9022561 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phase 1 of the Trials of Hypertension Prevention was conducted in 2182 adults, aged 35-54 y, with diastolic blood pressure of 80-89 mm Hg to test the feasibility and blood pressure-lowering effects of seven nonpharmacologic interventions (weight loss, sodium reduction, stress management, and supplementation with calcium, magnesium, potassium, and fish oil). At 6 and 18 mo, weight loss and sodium reduction were well-tolerated and produced significant declines in systolic and diastolic blood pressures (-2.9/-2.4 and -2.1/-1.2 mm Hg for weight loss and sodium reduction, respectively, at 18 mo). None of the other interventions lowered blood pressure significantly at either the 6- or 18-mo follow-up visits. These results suggest that both weight loss and sodium reduction provide an effective means to prevent hypertension. The long-term effects of both of these interventions are being tested in phase 2 of the trial. |
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Authors:
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P K Whelton; S K Kumanyika; N R Cook; J A Cutler; N O Borhani; C H Hennekens; L H Kuller; H Langford; D W Jones; S Satterfield; N L Lasser; J D Cohen |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 65 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1997 Feb |
Date Detail:
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Created Date: 1997-02-26 Completed Date: 1997-02-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 652S-660S Citation Subset: AIM; IM |
Affiliation:
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Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University School of Hygiene and Public Health, Baltimore, USA. pwhelton@mailhost.tcs.tulane.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure Body Weight Diet, Sodium-Restricted* Female Follow-Up Studies Humans Hypertension / epidemiology, prevention & control* Incidence Male Middle Aged Patient Compliance Quality of Life Risk Factors Sodium / urine Sodium, Dietary / administration & dosage Stress, Physiological / prevention & control Weight Loss |
| Chemical | |
Reg. No./Substance:
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0/Sodium, Dietary; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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