Document Detail


Efficacy of new microprocessed phototherapy system with five high intensity light emitting diodes (Super LED).
MedLine Citation:
PMID:  17551656     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To evaluate the efficacy of a microprocessed phototherapy (PT) system with five high intensity light emitting diodes (Super LED) for the treatment of neonatal hyperbilirubinemia of premature infants. METHODS: Randomized clinical trial using Super LED phototherapy in the study group and twin halogen spotlight phototherapy in the control group. A stratified blocked randomization, based on birth weight, was performed. The duration of phototherapy and the rate of decrease of total serum bilirubin (TSB) concentration in the first 24 hours of treatment were the main outcome measures. RESULTS: We studied 88 infants, 44 in the Super LED group and 44 in the halogen spotlight PT group. The demographic characteristics of the patients in both groups were similar. Infants in the Super LED group had a similar mean initial serum bilirubin level (10.1+/-2.4 mg%) to those receiving halogen spotlight treatment (10.9+/-2.0 mg%). After 24 hours of treatment, the decrease in total serum bilirubin levels was significantly greater in the Super LED group (27.9 vs. 10.7%, p<0.01) and duration of phototherapy was significantly shorter in this group (36.8 h vs. 63.8 h, p<0.01). After 24 hours of treatment, a significantly greater number of patients receiving Super LED phototherapy had reached serum bilirubin concentrations low enough to allow withdrawal of treatment (23 vs. 10, p<0.01). CONCLUSIONS: Our results demonstrate that the efficacy of Super LED phototherapy for treating hyperbilirubinemia in premature infants was significantly better than halogen phototherapy.
Authors:
Bianca M R Martins; Manoel de Carvalho; Maria E L Moreira; José M A Lopes
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Jornal de pediatria     Volume:  83     ISSN:  0021-7557     ISO Abbreviation:  J Pediatr (Rio J)     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2007-06-06     Completed Date:  2008-02-05     Revised Date:  2008-09-11    
Medline Journal Info:
Nlm Unique ID:  2985188R     Medline TA:  J Pediatr (Rio J)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  253-8     Citation Subset:  IM    
Affiliation:
Programa em Saúde da Criança e da Mulher, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Bilirubin / blood*
Case-Control Studies
Humans
Hyperbilirubinemia, Neonatal / therapy*
Infant, Newborn
Infant, Premature
Phototherapy / instrumentation*,  methods
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
635-65-4/Bilirubin
Comments/Corrections
Comment In:
J Pediatr (Rio J). 2007 Nov-Dec;83(6):576; author reply 577   [PMID:  18074065 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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