Document Detail

Efficacy of a new fractional CO2 laser in the treatment of photodamage and acne scarring.
MedLine Citation:
PMID:  20666827     Owner:  NLM     Status:  MEDLINE    
This study evaluates the efficacy and safety of a novel fractional CO(2) laser device for improving facial rhytids, hyperpigmentation, enlarged pores, skin laxity, and acne scarring. Subjects (n= 15) were treated three to five times at 3-week intervals. Biopsy specimens were used to evaluate healing response and neocollagenesis. Clinical improvement was rated on a quartile rating scale from digital photographs. Subject discomfort during treatment was evaluated on a scale of 0 to 5. Fourteen subjects who completed the study achieved good to excellent improvement in overall appearance, with 60% rated excellent. Improvement in photodamage was good to excellent in 92% of subjects, and reduction in rhytids was good to excellent in 85%. A total of 79% of subjects achieved good to excellent improvement in pore sizes and skin laxity. Subject discomfort during treatment was 3.0 +/- 0.7. Erythema persisted for 2-3 days, and subjects resumed normal activities 1-2 days after the procedure. Histological slides after a single treatment showed new collagen formation. The SmartSkin fractional CO(2) system (Cynosure, Inc., Westford, MA, USA) provides significant improvement for the treatment of facial wrinkles, hyperpigmentation, pore size, and skin laxity associated with photodamage.
Bruce Katz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Dermatologic therapy     Volume:  23     ISSN:  1529-8019     ISO Abbreviation:  Dermatol Ther     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-07-29     Completed Date:  2010-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9700070     Medline TA:  Dermatol Ther     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  403-6     Citation Subset:  IM    
Department of Dermatology, Mt. Sinai School of Medicine, JuvaSkin & Laser Center, New York, New York, USA.
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MeSH Terms
Acne Vulgaris / complications*
Aged, 80 and over
Cicatrix / etiology,  surgery*
Collagen / biosynthesis,  blood
Cosmetic Techniques
Hyperpigmentation / surgery
Lasers, Gas / adverse effects,  therapeutic use*
Middle Aged
Patient Satisfaction
Skin Aging*
Treatment Outcome
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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