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Efficacy of modified minimally invasive surgical technique in the treatment of human intrabony defects with or without use of rhPDGF-BB gel - a randomized controlled trial.
MedLine Citation:
PMID:  23167912     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: To evaluate the efficacy of modified minimally invasive surgical technique (M-MIST) technique with local delivery of recombinant human platelet derived growth factor (rhPDGF-BB) gel in the treatment of intrabony defects. MATERIAL AND METHODS: Twenty-four healthy subjects were included in the present double-blinded, randomized, controlled study. Test group was treated with M-MIST and rhPDGF-BB and control group with M-MIST alone. RESULTS: The mean probing depth (PD), clinical attachment level (CAL) and gingival recession, cementoenamel junction to base of the defect (CEJ-BD), defect depth (DD) and cementoenamel junction to alveolar crest (CEJ-AC), at baseline to 6 months post-operatively in both the groups were statistically significant. Inter-group comparison for gain in attachment level (CAL-G), probing depth reduction (PD-R) and change in gingival margin position linear bone growth (LBG), percentage bone fill, residual defect depth (residual DD) and the change in alveolar crest position revealed no statistically significant differences. Gain in CAL and LBG was 3 ± 0.89 mm and 1.89 ± 0.6 in test group and 2.64 ± 0.67 mm and 1.85 ± 1.18 mm in control group, respectively, and did not show statistical significance. CONCLUSIONS: The improvement in both groups could be attributed to the novel surgical technique rather than addition of rhPDGF-BB.
Authors:
Ashank Mishra; Haritha Avula; Krishnajaneya R Pathakota; Jayakumar Avula
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-21
Journal Detail:
Title:  Journal of clinical periodontology     Volume:  -     ISSN:  1600-051X     ISO Abbreviation:  J. Clin. Periodontol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425123     Medline TA:  J Clin Periodontol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Department of Periodontics, Sri Sai College of Dental Surgery, Vikarabad, India.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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