| Efficacy of minimal dose aprotinin in open heart procedures. | |
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MedLine Citation:
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PMID: 17846475 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In a randomized double blind study, 30 patients posted for CABG surgery were assigned to 3 groups of 10 each. Group A received 140 mg (1,000,000 KIU) of aprotinin after induction of anaesthesia but before sternotomy, an equal amount in the pump prime and a maintenance dose of 70 mg/hr throughout cardiopulmonary bypass (standard dose). Group B received placebo after induction of anaesthesia, 70 mg (500,000 KIU) aprotinin in the pump prime with a placebo as a maintenance dose (minimal dose). Group C received a placebo after induction of anaesthesia, in the prime and as a maintenance dose (control group). The mean chest closure times were insignificantly lower in the aprotinin groups; 35.83 +/- 13.93 mins in group A and 37.5 +/- 10 mins in group B as against 57.25 +/- 26.54 mins in group C. Post-operative haemoglobin loss was significantly lower (P<0.01) in aprotinin groups, 5.42 +/- 1.6 gm in group A and 6.28 +/- 2.49 gms in group B, as against 39.77 +/- 27.51 gm in group C. Whole blood transfusion requirement was also significantly reduced from 4.12 +/- 1.79 units in the control group to 2.5 +/- 0.75 units in group A (p < 0.05) and 2 +/- 1.3 units (p<0.01) in group B. We conclude that a minimal dose of aprotinin 70 mg (500,000 KIU) is effective in reducing postoperative blood loss, blood transfusion requirement and is economical. |
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Authors:
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M M Maddali; M Das; R Kausalya |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of cardiac anaesthesia Volume: 2 ISSN: 0971-9784 ISO Abbreviation: Ann Card Anaesth Publication Date: 1999 Jan |
Date Detail:
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Created Date: 2007-09-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9815987 Medline TA: Ann Card Anaesth Country: India |
Other Details:
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Languages: eng Pagination: 10-4 Citation Subset: - |
Affiliation:
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Department of Cardiac Anaesthesiology, Vijaya Heart Foundation, Vijaya Hospital, Chennai, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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