Document Detail


Efficacy of minimal dose aprotinin in open heart procedures.
MedLine Citation:
PMID:  17846475     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
In a randomized double blind study, 30 patients posted for CABG surgery were assigned to 3 groups of 10 each. Group A received 140 mg (1,000,000 KIU) of aprotinin after induction of anaesthesia but before sternotomy, an equal amount in the pump prime and a maintenance dose of 70 mg/hr throughout cardiopulmonary bypass (standard dose). Group B received placebo after induction of anaesthesia, 70 mg (500,000 KIU) aprotinin in the pump prime with a placebo as a maintenance dose (minimal dose). Group C received a placebo after induction of anaesthesia, in the prime and as a maintenance dose (control group). The mean chest closure times were insignificantly lower in the aprotinin groups; 35.83 +/- 13.93 mins in group A and 37.5 +/- 10 mins in group B as against 57.25 +/- 26.54 mins in group C. Post-operative haemoglobin loss was significantly lower (P<0.01) in aprotinin groups, 5.42 +/- 1.6 gm in group A and 6.28 +/- 2.49 gms in group B, as against 39.77 +/- 27.51 gm in group C. Whole blood transfusion requirement was also significantly reduced from 4.12 +/- 1.79 units in the control group to 2.5 +/- 0.75 units in group A (p < 0.05) and 2 +/- 1.3 units (p<0.01) in group B. We conclude that a minimal dose of aprotinin 70 mg (500,000 KIU) is effective in reducing postoperative blood loss, blood transfusion requirement and is economical.
Authors:
M M Maddali; M Das; R Kausalya
Related Documents :
8970345 - Treatment of cat allergy with t-cell reactive peptides.
10475325 - The effect of olprinone compared with milrinone on diaphragmatic muscle function in dogs.
16769615 - Combined immunologic and anti-angiogenic therapy reduces hepatic micrometastases in a m...
23603995 - Comparison between calcitriol and calcitriol plus low-dose cinacalcet for the treatment...
12473415 - Reproductive effects of deltamethrin on male offspring of rats exposed during pregnancy...
10049275 - Safety and single-dose pharmacokinetics of abacavir (1592u89) in human immunodeficiency...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of cardiac anaesthesia     Volume:  2     ISSN:  0971-9784     ISO Abbreviation:  Ann Card Anaesth     Publication Date:  1999 Jan 
Date Detail:
Created Date:  2007-09-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815987     Medline TA:  Ann Card Anaesth     Country:  India    
Other Details:
Languages:  eng     Pagination:  10-4     Citation Subset:  -    
Affiliation:
Department of Cardiac Anaesthesiology, Vijaya Heart Foundation, Vijaya Hospital, Chennai, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Anaesthesiologist in the net.
Next Document:  Coronary Artery Bypass Grafting without Cardiopulmonary Bypass: Improvement in Cardiac Function Foll...