Document Detail

Efficacy of micafungin in treating four premature infants with candidiasis.
MedLine Citation:
PMID:  19405920     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although clinical experience in neonates with candidiasis exists for amphotericin B and fluconazole, these standard treatments are often hindered by drug-associated toxicity or development of resistant strains. The aim of the present study was therefore to investigate the efficacy and tolerability of a new antifungal agent, micafungin (MCFG), for treating Candida infections in premature infants. METHODS: This was a retrospective cohort study. Premature infants diagnosed with Candida infections from October 2003 to July 2004 were brought to the neonatal intensive care unit at the Center of Perinatal Medicine, Nara Medical University Hospital. Four newborns were given 0.5-1.0 mg/kg per day micafungin. RESULTS: Four premature infants (mean +/- SD gestational age, 24.1 +/- 0.9 weeks; mean +/- SD birthweight, 579.3 +/- 80.5 g) experienced complications from Candida infection; two cases of the fungal infection were caused by Candida glabrata and two cases were caused by Candida albicans. MCFG was administered at 0.5 or 1.0 mg/kg per day (mean dosage days, 9.8 +/- 3.1 days) and it decreased beta-D-glucan levels while improving clinical symptoms in all cases. Additionally, there were no apparent side-effects. CONCLUSION: MCFG is both effective and tolerable for use in premature infants suffering from Candida infections.
Chiharu Kawaguchi; Ikuyo Arai; Hajime Yasuhara; Reiko Sano; Toshiya Nishikubo; Yukihiro Takahashi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  51     ISSN:  1442-200X     ISO Abbreviation:  Pediatr Int     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-01     Completed Date:  2009-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  220-4     Citation Subset:  IM    
Division of Neonatal Intensive Care, Perinatal Center, Nara Medical Hospital University Hosptial, Kashihara, Japan.
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MeSH Terms
Antifungal Agents / therapeutic use*
Candidiasis / blood,  drug therapy*
Echinocandins / therapeutic use*
Infant, Extremely Low Birth Weight*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / drug therapy*
Lipopeptides / therapeutic use*
Retrospective Studies
Treatment Outcome
beta-Glucans / blood
Reg. No./Substance:
0/Antifungal Agents; 0/Echinocandins; 0/Lipopeptides; 0/beta-Glucans; 0/micafungin

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