Document Detail


Efficacy of metoclopramide and dexamethasone for postoperative nausea and vomiting: a double-blind clinical trial.
MedLine Citation:
PMID:  20795444     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Postoperative nausea and vomiting are common complications of anaestnesia. This double-blind clinical trial assessed the incidence of nausea and vomiting after cataract surgery with intravenous anaesthesia in 100 patients randomly assigned to preinduction placebo (saline), metoclopramide (10 mg), dexamethasone (8 mg) or the 2 drugs combined. The incidence of nausea in the recovery room was 44% with placebo, 20% with metoclopramide, 16% with dexamethasone and 8% with the combination. The incidence of vomiting was 20%, 4%, 4% and 0% respectively in the 4 groups. Metoclopramide plus dexamethasone combination significantly decreased nausea and vomiting both in the recovery room and 24 hours afterwards and is recommended for high-risk groups, especially in outpatient surgeries.
Authors:
M Entezariasl; M Khoshbaten; K Isazadehfar; G Akhavanakbari
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ     Volume:  16     ISSN:  1020-3397     ISO Abbreviation:  East. Mediterr. Health J.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-08-27     Completed Date:  2010-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9608387     Medline TA:  East Mediterr Health J     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  300-3     Citation Subset:  IM    
Affiliation:
Department of Anaesthesiology, Ardebil University of Medical Sciences, Ardebil, Islamic Republic of Iran.
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MeSH Terms
Descriptor/Qualifier:
Aged
Analysis of Variance
Antiemetics / therapeutic use*
Cataract Extraction / adverse effects
Chi-Square Distribution
Dexamethasone / therapeutic use*
Double-Blind Method
Drug Therapy, Combination
Female
Humans
Incidence
Iran / epidemiology
Male
Metoclopramide / therapeutic use*
Middle Aged
Postoperative Nausea and Vomiting / epidemiology,  etiology,  prevention & control*
Preanesthetic Medication / methods*
Premedication / methods*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antiemetics; 364-62-5/Metoclopramide; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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