Document Detail


Efficacy of methyl 5(6)-(alpha-hydroxyphenylmethyl) benzimidazole-2-carbamate, a metabolite of mebendazole, against developing forms of experimental helminth parasites.
MedLine Citation:
PMID:  1794854     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Methyl 5(6)-(alpha-hydroxyphenylmethyl) benzimidazole-2- carbamate, a metabolite of mebendazole, was evaluated against metamorphic forms of Ancylostoma ceylanicum in hamsters, Nippostrongylus brasiliensis in rats and cysticercoids of Hymenolepis nana in grain beetles. The test compound offered better action than mebendazole except against H. nana cysticercoids where the activity of the compound and mebendazole was comparable, but was inferior to the standard cestodicidal drug, praziquantel. The results suggest that the action was better by ip route compared to per os route of drug administration.
Authors:
S Gupta; J K Srivastava; M K Jain; J C Katiyar; J Singh; D S Bhakuni
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian journal of experimental biology     Volume:  29     ISSN:  0019-5189     ISO Abbreviation:  Indian J. Exp. Biol.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1992-04-08     Completed Date:  1992-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0233411     Medline TA:  Indian J Exp Biol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  645-8     Citation Subset:  IM    
Affiliation:
Division of Parasitology, Central Drug Research Institute, Lucknow, India.
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MeSH Terms
Descriptor/Qualifier:
Ancylostoma / drug effects*,  growth & development
Animals
Anthelmintics / pharmacology*
Beetles
Hymenolepis / drug effects*,  growth & development
Larva
Mebendazole / analogs & derivatives*,  pharmacology
Nippostrongylus / drug effects*,  growth & development
Praziquantel / pharmacology
Rodentia
Chemical
Reg. No./Substance:
0/Anthelmintics; 31431-39-7/Mebendazole; 55268-74-1/Praziquantel; 60254-95-7/5-hydroxymebendazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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