Document Detail


Efficacy of methotrexate in rheumatoid arthritis.
MedLine Citation:
PMID:  9621475     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rheumatoid arthritis is a common inflammatory articular disorder in Bangladesh. Methotrexate has proved to be an effective and relatively safe disease modifying drug for this disease. A quasiexperimental trial of the efficacy of methotrexate in rheumatoid arthritis was carried out in the Rheumatology Clinic, Institute of Postgraduate Medicine & Research, Dhaka during the period between July 1992 and September 1993. Thirty eight patients fulfilling the revised ARA criteria were given methotrexate in a total weekly dose of 7.5 to 15 mg. They were followed up at weekly intervals for one month and then monthly for a total duration of six months. Twenty three subjects eventually completed the trial. The trial showed significant differences in the disease activity indices at the end of six months. The decline of activity was noted at the end of one month. As a whole the response was complete in 4(17%), marked in 14(61%), moderate in 4(17%) and nil in 1(4%). Adverse effects occurred in 27 subjects. They were mild and transient in 22. Methotrexate appeared to be an acceptable DMARD for our rheumatoid arthritis population.
Authors:
M L Ali; M N Alam; S A Haq; K K Das; P K Baral
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Publication Detail:
Type:  Case Reports; Clinical Trial; Journal Article    
Journal Detail:
Title:  Bangladesh Medical Research Council bulletin     Volume:  23     ISSN:  0377-9238     ISO Abbreviation:  Bangladesh Med Res Counc Bull     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-07-08     Completed Date:  1998-07-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7607686     Medline TA:  Bangladesh Med Res Counc Bull     Country:  BANGLADESH    
Other Details:
Languages:  eng     Pagination:  72-6     Citation Subset:  IM    
Affiliation:
Department of Medicine, Institute of Postgraduate Medicine & Research, Dhaka.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
Antirheumatic Agents / adverse effects,  therapeutic use*
Arthritis, Rheumatoid / complications,  drug therapy*
Asthma / complications
Drug Administration Schedule
Female
Humans
Male
Methotrexate / adverse effects,  therapeutic use*
Middle Aged
Prospective Studies
Remission Induction
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antirheumatic Agents; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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