Document Detail

Efficacy of metformin supplementation during ovarian stimulation of lean PCOS patients undergoing in vitro fertilization.
MedLine Citation:
PMID:  19306135     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the effect of metformin addition during ovarian hyperstimulation on cycle parameters and outcome of in vitro fertilization (IVF) treatment in polycystic ovary syndrome (PCOS) patients with a body mass index (BMI) <28 kg/m(2). DESIGN: Retrospective review of patients' records. SETTING: Istanbul Memorial Hospital Assisted Reproductive Treatment Unit. POPULATION: A total of 339 non-obese PCOS patients undergoing IVF were evaluated according to the supplementation of metformin. METHODS: Cycle parameters and IVF outcomes of 220 patients given metformin were compared to those of 119 patients treated without metformin. MAIN OUTCOME MEASURES: Implantation and pregnancy rates. RESULTS: Metformin co-treatment led to significantly lower peak E2 levels (3,481 pg/ml vs. 4,192 pg/ml; p <0.0001). However, gonadotropin consumption, stimulation duration, numbers of total and mature oocytes retrieved, fertilization rate, and ratio of grade I embryos developed were similar in both groups. In the metformin administered group, significantly higher implantation (25% vs. 18%; p=0.003) and pregnancy rates (58% vs. 45%; p=0.04) were achieved. Abortion and moderate-severe ovarian hyperstimulation syndrome rates were found to be similar in both groups. CONCLUSIONS: Although metformin use was especially and strongly recommended in obese PCOS cases, its supplementation during IVF in PCOS patients with a BMI <28 kg/m(2) was observed to be beneficial and efficacious.
Banu Kumbak; Semra Kahraman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  88     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-30     Completed Date:  2009-05-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  563-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Yeditepe University, Istanbul, Turkey.
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MeSH Terms
Blood Glucose / analysis,  metabolism
Body Mass Index
Case-Control Studies
Chorionic Gonadotropin / blood,  pharmacology
Dinoprostone / blood,  pharmacology
Embryo Implantation
Embryo Transfer
Estradiol / blood
Fertilization in Vitro
Follicle Stimulating Hormone / blood
Gonadotropin-Releasing Hormone / antagonists & inhibitors
Hypoglycemic Agents / therapeutic use*
Infertility, Female / epidemiology,  therapy
Insulin / blood
Insulin Resistance
Luteinizing Hormone / blood
Metformin / therapeutic use*
Ovarian Hyperstimulation Syndrome / epidemiology
Ovulation Induction / methods*
Polycystic Ovary Syndrome / drug therapy*
Pregnancy Rate*
Retrospective Studies
Treatment Outcome
Turkey / epidemiology
Reg. No./Substance:
0/Blood Glucose; 0/Chorionic Gonadotropin; 0/Hypoglycemic Agents; 11061-68-0/Insulin; 33515-09-2/Gonadotropin-Releasing Hormone; 363-24-6/Dinoprostone; 50-28-2/Estradiol; 657-24-9/Metformin; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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