Document Detail

Efficacy of metaphylactic florfenicol therapy during natural outbreaks of bovine respiratory disease.
MedLine Citation:
PMID:  19000268     Owner:  NLM     Status:  MEDLINE    
The efficacy of an injectable formulation of florfenicol (300 mg/mL) as metaphylactic control of naturally occurring bovine respiratory disease (BRD) was evaluated in two double-blind randomly controlled field studies on two Dutch veal calf herds (A and B). Cattle aged not older than 3 months and in the direct presence of calves with clinical respiratory disease were randomly allocated to treatment with 40 mg/kg florfenicol subcutaneously (s.c.) a positive control treatment (12.5 mg/kg tilmicosin p.o. twice daily for five consecutive days in herd A, and 12.5 mg/kg doxycycline p.o. twice daily for five consecutive days in herd B), or a negative control (one placebo saline s.c. administration on D0). The predominant respiratory pathogens present in pretreatment respiratory samples from affected animals were Mycoplasma bovis and Pasteurella multocida in outbreaks A and B, respectively. Metaphylactic administration of florfenicol resulted in a statistically significant weight gain, decreased rectal temperature for five consecutive days after treatment and decreased metaphylactic failure percentages compared with both positive and negative control groups. In summary, these studies demonstrated that a single s.c. injection of florfenicol is effective and practical for control of the bacterial component of BRD in veal calves.
B Catry; L Duchateau; J Van de Ven; H Laevens; G Opsomer; F Haesebrouck; A De Kruif
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of veterinary pharmacology and therapeutics     Volume:  31     ISSN:  1365-2885     ISO Abbreviation:  J. Vet. Pharmacol. Ther.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-11-12     Completed Date:  2009-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910920     Medline TA:  J Vet Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  479-87     Citation Subset:  IM    
Department of Obstetrics, Reproduction and Herd Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Body Temperature
Body Weight
Cattle Diseases / drug therapy*,  epidemiology
Disease Outbreaks / prevention & control,  veterinary*
Mycoplasma Infections / drug therapy,  veterinary*
Mycoplasma bovis / isolation & purification*,  pathogenicity
Pasteurella Infections / drug therapy,  veterinary*
Pasteurella multocida / isolation & purification*,  pathogenicity
Respiratory Tract Infections / drug therapy,  microbiology,  veterinary*
Thiamphenicol / analogs & derivatives*,  therapeutic use
Tylosin / analogs & derivatives*,  therapeutic use
Reg. No./Substance:
0/Anti-Bacterial Agents; 108050-54-0/tilmicosin; 1401-69-0/Tylosin; 15318-45-3/Thiamphenicol; 73231-34-2/florfenicol

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