Document Detail

Efficacy of meal replacements versus a standard food-based diet for weight loss in type 2 diabetes: a controlled clinical trial.
MedLine Citation:
PMID:  18267998     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The purpose of this study is to compare the efficacy of a portion-controlled meal replacement diet (PCD) to a standard diet (SD) based on recommendations by the American Diabetes Association in achieving and maintaining weight loss among obese participants with type 2 diabetes. METHODS: This study is a university-based, controlled clinical trial. Participants were 119 men and women with diabetes with a body mass index between 25 and 40 kg/m(2), assigned randomly to one of two 34-week, 75% of predicted energy need diets (portion controlled or standard, self-selected, food based) and then followed by 1-year maintenance. RESULTS: Using intention-to-treat analyses, weight loss at 34 weeks and weight maintenance at 86 weeks was significantly better on PCD versus SD. Approximately 40% of the PCD participants lost > or =5% of their initial weight compared with 12% of those on the SD. Significant improvements in biochemical and metabolic measures were observed at 34 weeks in both groups. The retention rate and self-reported ease of adherence in the PCD group were significantly higher throughout the study. CONCLUSIONS: A diet using portion-controlled meal replacements yielded significantly greater initial weight loss and less regain after 1 year of maintenance than a standard, self-selected, food-based diet. As PCDs may help obese patients with type 2 diabetes adhere to a weight control program, diabetes educators may consider recommending them as part of a comprehensive approach to weight control.
Lawrence J Cheskin; Amy M Mitchell; Ami D Jhaveri; Andrea H Mitola; Lisa M Davis; Rebecca A Lewis; Mary A Yep; Thomas W Lycan
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Diabetes educator     Volume:  34     ISSN:  0145-7217     ISO Abbreviation:  Diabetes Educ     Publication Date:    2008 Jan-Feb
Date Detail:
Created Date:  2008-02-12     Completed Date:  2008-04-29     Revised Date:  2009-10-01    
Medline Journal Info:
Nlm Unique ID:  7701401     Medline TA:  Diabetes Educ     Country:  United States    
Other Details:
Languages:  eng     Pagination:  118-27     Citation Subset:  N    
Johns Hopkins Bloomberg School of Public Health, Department of International Health, Center for Human Nutrition, Baltimore, MD 21205-2179, USA.
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MeSH Terms
Diabetes Mellitus, Type 2 / physiopathology*,  rehabilitation*
Diabetic Diet*
Energy Intake
Middle Aged
Patient Education as Topic
Treatment Outcome
Weight Loss*
Comment In:
Curr Diab Rep. 2009 Oct;9(5):329-30   [PMID:  19793500 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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