Document Detail

Efficacy and low vascular toxicity of embolization with radical versus anionic polymerization of n-butyl-2-cyanoacrylate (NBCA). An experimental study in the swine.
MedLine Citation:
PMID:  12717295     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: To compare the efficacy and vascular toxicity of embolization with radical (NBCA+metacryloxysulpholane=CS) versus conventional anionic (NBCA alone=CA) polymerization of NBCA. MATERIALS AND METHODS: Under continuous digital subtracted angiography (DSA) recordings, a 0.2 mL volume of identical glue mixtures were injected in a single-step procedure, concomitantly, in left and right (with CS and CA, respectively) renal arterial branches (RAB) and ascending pharyngeal arteries (APA) in 8 swines. Arterial histopathology and morphometry of inflammation were investigated at 2 weeks. RESULTS: Complete embolization was achieved with equivalent cast homogeneity on DSA with both NBCA mixtures in RAB and APA. Inflammatory crowns in APA and RAB were significantly lower in CS - than in CA-treated sites (p<0.001). CS plug was scarcely adhesive to the vascular wall, and pulled apart from the wall by a residual thrombotic lining; in contrast with CA casts that were strongly adhesive to walls with endothelium stripping. CONCLUSIONS: Anionic and radical polymerization of NBCA embolization was identical with regards to occlusion rate; whereas radical pathway of polymerization with cyanoacrylates lowered histotoxicity with a less sustained adhesiveness of casts against vascular walls.
O Levrier; C Mekkaoui; P H Rolland; K Murphy; P Cabrol; G Moulin; J M Bartoli; C Raybaud
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of neuroradiology. Journal de neuroradiologie     Volume:  30     ISSN:  0150-9861     ISO Abbreviation:  J Neuroradiol     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-04-28     Completed Date:  2003-08-05     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  7705086     Medline TA:  J Neuroradiol     Country:  France    
Other Details:
Languages:  eng     Pagination:  95-102     Citation Subset:  IM    
Laboratoire d'H?modynamique et de M?canique Cardiovasculaire, Facult? de M?decine Marseille, H?pital de La Timone, France.
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MeSH Terms
Angiography, Digital Subtraction
Arteritis / pathology
Cyanoacrylates / toxicity*
Embolization, Therapeutic / methods*
Enbucrilate / toxicity*
Endothelium, Vascular / drug effects*,  pathology,  radiography
Foreign-Body Reaction / pathology
Structure-Activity Relationship
Reg. No./Substance:
0/Cyanoacrylates; 0/Polymers; 0/glubran 2; 6606-65-1/Enbucrilate

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