Document Detail

Efficacy of low dose hCG on oocyte maturity for ovarian stimulation in poor responder women undergoing intracytoplasmic sperm injection cycle: a randomized controlled trial.
MedLine Citation:
PMID:  22956348     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the effect of late follicular administration of low dose hCG on oocyte maturity in poor responding women undergoing intracytoplasmic sperm injection (ICSI).
MATERIALS AND METHODS: This prospective randomized pilot trial was performed on 73 poor responders undergoing ICSI, in Reproductive Biomedicine Research Center, Royan Institute, Tehran, Iran. All eligible patients underwent a GnRH-a long protocol and were randomly allocated into three study groups for ovarian stimulation: groupA received recombinant FSH alone, group B received recombinant FSH supplemented by 100 IU hCG. Group C received recombinant FSH supplemented by 200 IU hCG. The main endpoint was the number of metaphase II oocytes retrieved.
RESULTS: Of 78 poor responding patients entered to this study, 73 women were considered eligible for enrolment. Of these, 26 women were allocated to receive only recombinant FSH, 24 patients allocated to receive recombinant FSH and 100 IU hCG and 23 patients were assigned to receive recombinant FSH and 200 IU hCG. Number of oocytes retrieved were significantly higher in group B compared to group A (6.5 ± 3.3 versus 4.0 ± 2.3; P = .03). Other cycle and clinical outcomes were comparable between three groups.
CONCLUSIONS: The present study demonstrated that adding 100 IU hCG to rFSH in a GnRH agonist cycle in poor responders improve response to stimulation whereas the number of metaphase II oocytes remains comparable between groups. The existence of a possible trend toward higher mature oocytes and lower total dosage rFSH in patients received 100 or 200 IU hCG is probably due to the small sample size that means further large clinical trials in a more homogenous population is required (clinical trial registration number; NCT01509833).
Tahereh Madani; Ladan Mohammadi Yeganeh; Shabnam Khodabakhshi; Mohammad Reza Akhoond; Fatemeh Hasani
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2012-09-07
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  29     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-30     Completed Date:  2013-06-06     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1213-20     Citation Subset:  IM    
Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, P.O Box:19395-4644, Tehran, Iran.
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MeSH Terms
Chorionic Gonadotropin / administration & dosage*
Drug Therapy, Combination
Follicle Stimulating Hormone / administration & dosage,  genetics
Oocytes / cytology*,  drug effects
Ovulation Induction / methods*
Prospective Studies
Recombinant Proteins / administration & dosage,  genetics
Sperm Injections, Intracytoplasmic / methods*
Treatment Outcome
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Recombinant Proteins; 9002-68-0/Follicle Stimulating Hormone

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