Document Detail

Efficacy of low dose captopril once daily in diuretic resistant hypertension.
MedLine Citation:
PMID:  3534846     Owner:  NLM     Status:  MEDLINE    
In 12 essential hypertensive patients insufficiently controlled by treatment with 50 mg hydrochlorothiazide, the blood pressure lowering effect of the addition of 25 mg captopril once daily was examined. Twenty four hour ambulatory blood pressure monitoring was performed using portable automatic recording devices before treatment, after 4 weeks of treatment with hydrochlorothiazide alone, and again after 4 weeks of combined treatment with captopril. The combined treatment yielded a marked additional blood pressure reduction in comparison with the previous medication of the diuretic alone. The additional antihypertensive effect of captopril lasted 24 hours. During the daytime between 08.00 h and 20.00 h the mean blood pressure was 158 +/- 13/100 +/- 8 mmHg before treatment. After treatment with hydrochlorothiazide alone it was 151 +/- 11/93 +/- 8 mmHg and after hydrochlorothiazide and captopril it was 140 +/- 13/88 +/- 9 mmHg. Our results indicate that the addition of only 25 mg captopril once a day to a diuretic may result in a marked additional blood pressure reduction or normalization in cases of insufficient control by the diuretic alone.
P Baumgart; W Tenschert; H Vetter
Related Documents :
12162936 - Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in atheroscl...
7781206 - Renal hemodynamics in essential hypertensives treated with losartan.
7527326 - Quinapril. a reappraisal of its pharmacology and therapeutic efficacy in cardiovascular...
3005576 - Angiotensin converting enzyme inhibitors as antihypertensive agents: 1-[(2-mercaptocycl...
19791416 - Local compressibilities in insulin as determined from pressure tuning hole burning expe...
10073476 - Ultrawide-band electromagnetic pulses induced hypotension in rats.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  62 Suppl 1     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1986  
Date Detail:
Created Date:  1986-12-05     Completed Date:  1986-12-05     Revised Date:  2009-10-22    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  127-30     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure / drug effects
Captopril / administration & dosage,  therapeutic use*
Drug Therapy, Combination
Hydrochlorothiazide / therapeutic use
Hypertension / blood,  drug therapy*
Middle Aged
Time Factors
Reg. No./Substance:
58-93-5/Hydrochlorothiazide; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Low dose captopril twice daily lowers blood pressure without disturbance of the normal circadian rhy...
Next Document:  Effects of captopril and of other antihypertensive drugs on cell membrane ion transport--a prelimina...