Document Detail


Efficacy of low-dose captopril given twice daily to patients with essential hypertension uncontrolled by a beta blocker plus thiazide diuretic.
MedLine Citation:
PMID:  6381166     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirty-two patients with moderate to severe essential hypertension whose supine diastolic blood pressure (SDBP) was greater than or equal to 95 mm Hg following 2 weeks' treatment with the optimal dosage of beta blocker-diuretic combination were randomly assigned to the addition of either captopril 25 mg or 50 mg b.i.d. After 6 weeks' treatment, if patients were not normalized (SDBP less than 95 mm Hg), the dose of captopril was doubled for a further 6 weeks. The addition of captopril led to a significant fall in standing and supine diastolic and systolic blood pressure at the end of the sixth and twelfth week of treatment. There was no difference in the change in blood pressure between the two groups. At the end of the study SDBP was normalized in 66% of patients and a further 12.5% had their SDBP reduced by greater than 10%. Captopril 25 or 50 mg administered twice daily proved to be a very effective antihypertensive agent when added to a beta blocker-diuretic combination in patients resistant to optimal doses of these drugs.
Authors:
G Muiesan; C Alicandri; E Agabiti-Rosei; R Fariello; E Montini; M L Muiesan; E Boni; A Cinquegrana; A Zaninelli
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of international medical research     Volume:  12     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:  1984  
Date Detail:
Created Date:  1984-10-19     Completed Date:  1984-10-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  221-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aldosterone / blood
Blood Pressure / drug effects
Captopril / therapeutic use*
Chlorthalidone / therapeutic use*
Dose-Response Relationship, Drug
Drug Therapy, Combination
Female
Humans
Hypertension / blood,  drug therapy*
Male
Middle Aged
Oxprenolol / therapeutic use*
Proline / analogs & derivatives*
Renin / blood
Chemical
Reg. No./Substance:
147-85-3/Proline; 52-39-1/Aldosterone; 62571-86-2/Captopril; 6452-71-7/Oxprenolol; 77-36-1/Chlorthalidone; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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