Document Detail

Efficacy of long-term sulfamethoxazole-trimethoprim therapy in a boy with hyperimmunoglobulin E syndrome.
MedLine Citation:
PMID:  9915108     Owner:  NLM     Status:  MEDLINE    
A boy with hyperimmunoglobulin E syndrome (HIE syndrome), who was successfully treated with long-term sulfamethoxazole-trimethoprim (SMX-TMP) is reported. He had been suffering from recurrent pruritic dermatitis soon after birth and had a significant high level of serum immunoglobulin E. Although an initiation of SMX-TMP therapy resulted in resolution of his clinical manifestations, cessation of the treatment exacerbated the symptoms. Chemoprophylaxis of other oral antibiotics, which were suitable for Staphylococcus aureus isolated from lesions of the patient were unsuccessful. Another trial of low-dose SMX-TMP therapy resulted in gradual subsidence of the clinical manifestations. From these observations, efficacy of SMX-TMP therapy to prevent bacterial infection in the patient is clinically apparent. Although precise mechanism of the therapy remains speculative, long-term SMX-TMP therapy might be of benefit and low clinical toxicity in HIE syndrome.
H Tanaka; R Ito; N Onodera; S Waga
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  186     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1999-04-07     Completed Date:  1999-04-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  61-6     Citation Subset:  IM    
Division of Pediatrics, Iwate Prefectural Kitakami Hospital, Japan.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Immunoglobulin E / blood
Job's Syndrome / blood,  drug therapy*,  microbiology,  physiopathology
Staphylococcus aureus / isolation & purification
Sulfamethoxazole / therapeutic use*
Time Factors
Trimethoprim / therapeutic use*
Reg. No./Substance:
0/Anti-Bacterial Agents; 37341-29-0/Immunoglobulin E; 723-46-6/Sulfamethoxazole; 738-70-5/Trimethoprim

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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