| Efficacy of local sclerosing agents on hemostasis of hepatic bleeding. | |
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MedLine Citation:
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PMID: 17629072 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Hepatic bleeding following abdominal trauma is a serious problem. The implementation of various materials and techniques have been attempted to prevent bleeding but a standard method is indefinite. METHODOLOGY: Hepatic resection model was performed on rats. The efficacy of hemostasis with Polidocanol and Tetradecyl Sulfate has been evaluated through the comparison of perioperative bleeding amount and preoperative and postoperative hematocrit levels in the 24th hour. Also, histopathologic changes on parenchyma have been compared at a microscopic level. RESULTS: Preoperative and postoperative hematocrit differences were 5.50 +/- 0.59 in Polidocanol group and 10 +/- 1.30 in Tetradecyl Sulfate group (MW: 2, p < 0.001). Perioperative bleeding amounts were: 1.50 +/- 0.20 mL in the Polidocanol group, 3.50 +/- 0.15 mL in the Tetradecyl Sulfate group and 7.50 +/- 0.41 mL in the Control Group. Upon comparison of perioperative bleeding amounts: the Control Group values were very high in comparison to the Polidocanol group (p < 0.001) and the Tetradecyl Sulfate group values were higher than those of the Polidocanol group (p < 0.05). CONCLUSIONS: Local sclerosing agents, especially Polidocanol, appear to be an effective alternative method in hemostasis of hepatic bleeding. |
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Authors:
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Erhan Aysan; Fatih Basak; Erdem Kinaci; Hamdi Tutuncu |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hepato-gastroenterology Volume: 54 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-07-16 Completed Date: 2007-08-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: Greece |
Other Details:
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Languages: eng Pagination: 1212-5 Citation Subset: IM |
Affiliation:
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General Surgery Department, S.B. Istanbul Education and Research Hospital Istanbul, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Hemorrhage / drug therapy* Hemostasis / drug effects* Liver Diseases / drug therapy* Polyethylene Glycols / pharmacology, therapeutic use* Rats Rats, Wistar Sclerosing Solutions / pharmacology, therapeutic use* Sodium Tetradecyl Sulfate / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Polyethylene Glycols; 0/Sclerosing Solutions; 1191-50-0/Sodium Tetradecyl Sulfate; 9002-92-0/polidocanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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