Document Detail


Efficacy of local molsidomine delivery from a hydrogel-coated angioplasty balloon catheter in the atherosclerotic porcine model.
MedLine Citation:
PMID:  12491015     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate the therapeutic effects of local molsidomine delivery via a hydrogel-coated angioplasty balloon catheter during overstretch angioplasty in atherosclerotic swine iliac vessels. Molsidomine is retained in the arterial wall after local delivery for more than 72 hr and is slowly metabolized into linsidomine, releasing nitric oxide (NO). METHODS: A hydrogel-coated angioplasty balloon catheter was used to both deliver drug locally (150 mg molsidomine or placebo in the contralateral vessel) and dilate iliac vessels in nine Pietrin pigs that had been on an atherogenic diet for 5 months. Animals were killed at 3 hr (n = 2), 24 hr (n = 3) and 3 months (n = 3) after treatment. Iliac arteries were examined for wall pulsatility, histomorphometry, cell proliferation and platelet aggregation. RESULTS: No significant therapeutic effects were detected 3 hr after treatment. At 24 hr, wall pulsatility, thromboresistance and vascular cell homeostasis were significantly restored in the molsidomine-treated versus placebo group. At 3 months, molsidomine inhibited restenotic lesion development, except in scarred areas of histologically detectable adventitial/medial dissection. CONCLUSION: Local delivery of concentrated molsidomine from a hydrogel-coated angioplasty balloon catheter resulted in early NO-dependent vasodilation/stress normalization and antithrombotic and antiproliferative effects. In the medium term, molsidomine inhibited restenosis in the absence of vessel dissection.
Authors:
Pierre H Rolland; Choukri Mekkaoui; Maria Palassi; Alain Friggi; Guy Moulin; Philippe Piquet; Jean-Michel Bartoli
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Publication Detail:
Type:  Journal Article     Date:  2002-12-20
Journal Detail:
Title:  Cardiovascular and interventional radiology     Volume:  26     ISSN:  0174-1551     ISO Abbreviation:  Cardiovasc Intervent Radiol     Publication Date:    2003 Jan-Feb
Date Detail:
Created Date:  2003-03-18     Completed Date:  2003-07-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8003538     Medline TA:  Cardiovasc Intervent Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  65-72     Citation Subset:  IM    
Affiliation:
School of Medicine, Faculté de Medicine, 27, Hemodynamics and Cardiovascular Mechanics Laboratory, Bld Jean-Moulin, F-13385 Marseille Cedex 5, France. Ph.Rolland@medecine.univ-mrs.fr
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Angioplasty, Balloon* / instrumentation
Animals
Arteriosclerosis / drug therapy*
Disease Models, Animal
Drug Delivery Systems / instrumentation*
Hydrogel*
Iliac Artery
Microscopy, Electron, Scanning
Molsidomine / administration & dosage*
Statistics, Nonparametric
Swine
Vasodilator Agents / administration & dosage*
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 25717-80-0/Molsidomine; 25852-47-5/Hydrogel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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