Document Detail


Efficacy of a live equine herpesvirus-1 (EHV-1) strain C147 vaccine in foals with maternally-derived antibody: protection against EHV-1 infection.
MedLine Citation:
PMID:  15253088     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
REASONS FOR PERFORMING STUDY: Currently, there is no recommended immunoprophylaxis against febrile respiratory diseases due to equine herpesvirus-1 (EHV-1) and -4 (EHV-4) in horses below age 5-6 months. This is because of interference by maternally-derived antibody (MDA) of vaccines. OBJECTIVE: Unweaned equine foals are an important reservoir of EHV-1 transmission; therefore, we experimentally assessed the efficacy of a live EHV-1 vaccine in foals age 1.4-3.5 months with MDA. METHODS: Following vaccination and challenge, parameters assessed were virus shedding in nasal mucus, leucocyte-associated viraemia, circulating virus neutralising antibody activity and clinical reactions. RESULTS: Controlled challenge showed that a single intranasal dose of the vaccine afforded partial but significant protection against febrile respiratory disease, virus shedding and viraemia due to EHV-1 infection, despite virus-neutralising MDA. CONCLUSIONS AND POTENTIAL RELEVANCE: The prospective vaccine would be a significant step forward in reducing the incidence of the disease caused by EHV-1 infection.
Authors:
J R Patel; S Didlick; H Bateman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Equine veterinary journal     Volume:  36     ISSN:  0425-1644     ISO Abbreviation:  Equine Vet. J.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-07-15     Completed Date:  2004-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173320     Medline TA:  Equine Vet J     Country:  England    
Other Details:
Languages:  eng     Pagination:  447-51     Citation Subset:  IM    
Affiliation:
Intervet UK Ltd., The Elms, Thicket Road, Houghton, Huntingdon, Cambridgeshire PE28 2BQ, UK.
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MeSH Terms
Descriptor/Qualifier:
Administration, Intranasal
Animals
Animals, Newborn / immunology*
Antibodies, Viral / blood*
Female
Herpesviridae Infections / immunology,  prevention & control,  veterinary*,  virology
Herpesvirus 1, Equid / immunology*
Herpesvirus 4, Equid / immunology*
Herpesvirus Vaccines*
Horse Diseases / immunology,  prevention & control*,  virology
Horses
Immunity, Maternally-Acquired
Male
Mucus / virology
Nasal Mucosa / virology
Neutralization Tests / veterinary
Treatment Outcome
Viremia / veterinary
Virus Shedding
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Herpesvirus Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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