Document Detail


Efficacy of lithium in rheumatoid arthritis with granulocytopenia (felty's syndrome). A preliminary report.
MedLine Citation:
PMID:  1131284     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lithium carbonate was given orally for 6 weeks in varying doses to 10 patients with Felty's syndrome. All patients receiving 900 mg of lithium daily showed statistically significant elevations in granulocyte count during therapy. The effect was usually noted within a week and did not persist when the drug was withdrawn. The percentage increase in mean absolute granulocyte count varied between 138% and 617% of control value in different patients; the lower values were observed in those patients with basal serum lithium concentrations less than 0.5 mEq/liter. It is concluded that a consistent rise in peripheral blood granulocytes was achieved by lithium carbonate in a dosage of 900 mg daily in patients with Felty's syndrome.
Authors:
R C Gupta; W A Robinson; C J Smyth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  18     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:    1975 Mar-Apr
Date Detail:
Created Date:  1975-08-07     Completed Date:  1975-08-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  179-84     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Felty's Syndrome / blood,  drug therapy*
Female
Granulocytes
Humans
Leukocyte Count
Lithium / administration & dosage,  blood,  therapeutic use*
Male
Middle Aged
Chemical
Reg. No./Substance:
7439-93-2/Lithium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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