Document Detail

Efficacy of a liquid-based thin layer method for cervical cancer screening in a population with a low incidence of cervical cancer.
MedLine Citation:
PMID:  10613975     Owner:  NLM     Status:  MEDLINE    
The performance of the ThinPrep(R) Pap Testtrade mark (TP) (Cytyc Corp., Boxborough, MA) for detection of cervical cancer precursors in a population with a low incidence of disease was evaluated. This prospective trial compared results obtained with TP to those obtained with the standard cytologic smear in women from the general community who were being screened for cervical cancer from January 1, 1995-December 31, 1997 by physicians in private practice (n x 130, 381 conventional examinations and 39,864 TP examinations). In the TP series there was a significant increase in the proportion of "satisfactory" examinations (91.9% TP vs. 72.2% conventional) and positive diagnoses (5.5% TP vs 2.4% conventional, odds ratio x 2.21; 95% confidence interval (CI), 2.08-2.34). The likelihood of detecting a high-grade squamous intraepithelial lesion (HSIL) by TP was significantly greater than in controls (odds ratio x 1.86; 95% CI, 1.68-2.06). Detection of low-grade squamous intraepithelial lesions (LSIL), or atypical squamous cells of undetermined significance (ASCUS), was significantly greater in the TP series than in controls (LSIL odds ratio x 3.41; 95% CI, 3.07-3.79; ASCUS odds ratio x 1.68; 95% CI, 1.56-1.82). A histologic lesion was confirmed in 141 (93%) of the biopsies for HSIL (130 HSIL or greater, 10 LSIL, 1 SIL not otherwise specified). In conclusion, both diagnostic sensitivity and sample adequacy were significantly improved using the ThinPrep(R) Pap test under routine conditions in an outpatient population with a low incidence of cervical cancer.
J Weintraub; A Morabia
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Diagnostic cytopathology     Volume:  22     ISSN:  8755-1039     ISO Abbreviation:  Diagn. Cytopathol.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-01-13     Completed Date:  2000-01-13     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8506895     Medline TA:  Diagn Cytopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  52-9     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Wiley-Liss, Inc.
Laboratoire Weintraub, Geneva, Switzerland.
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MeSH Terms
Mass Screening
Middle Aged
Predictive Value of Tests
Prospective Studies
Reagent Kits, Diagnostic
Sensitivity and Specificity
Uterine Cervical Neoplasms / diagnosis*,  epidemiology,  pathology
Vaginal Smears / methods*
Reg. No./Substance:
0/Reagent Kits, Diagnostic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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