Document Detail


Efficacy of linoleic acid administered rectally as monoglyceride.
MedLine Citation:
PMID:  3600208     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The potential of the rectal route for administration of essential fatty acids (EFA) as monoglyceride (MG) was investigated. EFA-deficient rats were supplemented with 14 mg linoleic acid/day for 3 days. Supplementation was either by oral administration as corn oil, orally as corn oil-derived MG or rectally as MG. The patterns of polyunsaturated fatty acids (PUFA) in liver and serum lipids, characteristic of EFA deficiency, were altered in the direction of normalcy in similar magnitude by all modes of supplementation, indicating that the rectal route may be useful for administration of EFA. The amounts of phospholipids (PL) and free fatty acids (FFA) in liver changed by all modes of administration. The magnitude of change of total PL and of FFA in liver depended upon the chemical form in which linoleic acid was administered and the route of administration, indicating that these factors affect lipid metabolism.
Authors:
A Christophe; E G Hill; R T Holman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lipids     Volume:  22     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-07-29     Completed Date:  1987-07-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  328-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Fatty Acids, Essential / deficiency
Glycerides
Linoleic Acid
Linoleic Acids / administration & dosage,  pharmacology*
Liver / metabolism
Phospholipids / analysis
Rats
Rectum
Suppositories
Grant Support
ID/Acronym/Agency:
AM 34931/AM/NIADDK NIH HHS; HL 08214/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Essential; 0/Glycerides; 0/Linoleic Acids; 0/Phospholipids; 0/Suppositories; 2197-37-7/Linoleic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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