Document Detail


Efficacy of linezolid compared to vancomycin in an experimental model of pneumonia induced by methicillin-resistant Staphylococcus aureus in ventilated pigs.
MedLine Citation:
PMID:  21926613     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE:: To assess the efficacy of linezolid compared with vancomycin in an experimental model of pneumonia induced by methicillin-resistant Staphylococcus aureus (MRSA) in ventilated pigs. METHODS:: Forty pigs (30 kg) were intubated and challenged via bronchoscopy with a suspension of 106 colony forming units of MRSA into every lobe. Afterwards, pigs were ventilated up to 96 hours. Twelve hours after bacterial inoculation, the animals were randomized into 4 groups of treatment: group 1, control; group 2, vancomycin twice daily; group 3, continuous infusion of vancomycin; and group 4, linezolid. Clinical and laboratory parameters were monitored throughout the study. Bacterial cultures of BAL fluid and lung tissue samples were performed at the end of the study. Measurements of histopathology derangements of lung samples and studies of intrapulmonary drug penetration were performed. RESULTS:: A total of 34 animals completed the study. No differences in clinical and laboratory parameters were observed. The percentage of BAL fluid and lung tissue samples with positive cultures for MRSA in controls and groups 2, 3, and 4 was respectively 75%, 11%, 11%, and 0% (p < .01); 52%, 9%, 24%, and 2.5% (p < .01). Histopathology studies demonstrated signs of pneumonia in 95%, 69%, 58%, and 57% and signs of severe pneumonia in 48%, 29%, 22%, and 0% of controls and groups 2, 3, and 4, respectively (p < .01). In addition, pharmacokinetics/pharmacodynamics profile in serum and lung tissue showed better results for linezolid compared with both vancomycin treatments. CONCLUSIONS:: In this animal model of MRSA pneumonia, linezolid showed a better efficacy than vancomycin showed because of a better pharmacokinetics/pharmacodynamics index.
Authors:
Pilar Martinez-Olondris; Montserrat Rigol; Dolors Soy; Laura Guerrero; Carlos Agusti; Maria Angels Quera; Gianluigi Li Bassi; Mariano Esperatti; Nestor Luque; Manto Liapikou; Xavier Filella; Francesc Marco; Jordi Puig de la Bellacasa; Antoni Torres
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-15
Journal Detail:
Title:  Critical care medicine     Volume:  -     ISSN:  1530-0293     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the Pneumology Service (PM-O, CA, GLB, ME, NL, ML, AT), Thorax Clinic Institute, Hospital Clinic, IDIBAPS (Institut d'Investigacions Biomèdiques Agustí Pi Sunyer), University of Barcelona, Barcelona, Spain; Cardiology Service (MR), Thorax Clinic Institute, Hospital Clinic, Red REDINSCOR RD06/0003/1002, Barcelona, Spain; Pharmacy Service (DS, LG), Hospital Clinic, Barcelona, Spain; CDB (MAQ, XF, FM, JPdlB), Hospital Clinic, Barcelona, Spain; CIBERES (CIBER de Enfermedades Respiratorias, 06/06/0028) (PM-O, MR, DS, LG, CA, ME, NL, AT), Mallorca, Spain.
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