| Efficacy and limits of sildenafil citrate in patients with arterial erectile dysfunction: role of peripheral arterial disease and cardiovascular comorbidities. | |
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MedLine Citation:
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PMID: 18958348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To evaluate whether the response to sildenafil administration in patients with arterial erectile dysfunction (ED) was related to their peak systolic velocity (PSV), peripheral atherosclerosis, cardiovascular risk factors (RF) and/or comorbidities at low cardiovascular risk. METHODS: We enrolled 97 patients with 1-2 RF and comorbidities, combined with arterial ED alone (group A, n = 27), ED plus atherosclerotic carotid artery (group B, n = 23), ED plus lower limb artery abnormalities (group C, n = 25), and ED plus carotid and lower limb artery abnormalities (group D, n = 22). Sildenafil efficacy (100 mg twice a week for 12 weeks) was also examined in patients with =or>3 RF, peripheral atherosclerosis and no cardiovascular comorbidities (group E, n = 20). RESULTS: Median PSV was 24.1, 21.0, 19.3, 14.5 and 17.5 cm/s in groups A, B, C, D and E, respectively. Sildenafil response was higher in group A patients (77.8%), intermediate in groups B and C (65.2% and 56%) and lowest in groups D (45.4%) and E (50%), and the response in latter two groups was significantly lower than in the other three groups. In addition, sildenafil response was negatively influenced by: =or>3 RF, peripheral atherosclerosis and no systemic comorbidity, or presence of 1-2 RF associated with extended atherosclerosis and comorbidities. The number of comorbidities was positively related to atherosclerosis localization or extension (25, 35, 38 and 47 in groups A, B, C and D, respectively). CONCLUSION: Low sildenafil efficacy in patients with arterial ED was associated with extended atherosclerosis. These patients should undergo extensive ultrasonography and a full cardiovascular examination. |
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Authors:
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Enzo Vicari; Mariano Malaguarnera; Sandro La Vignera; Fabio Calzavara; Carmelo Battiato; Aldo E Calogero |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Asian journal of andrology Volume: 10 ISSN: 1008-682X ISO Abbreviation: Asian J. Androl. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-29 Completed Date: 2009-02-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100942132 Medline TA: Asian J Androl Country: China |
Other Details:
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Languages: eng Pagination: 847-53 Citation Subset: IM |
Copyright Information:
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(c) 2008, Asian Journal of Andrology, SIMM and SJTU. All rights reserved. |
Affiliation:
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Department of Biomedical Sciences, University of Catania, Catania 95123, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arterial Occlusive Diseases / complications, drug therapy*, physiopathology Atherosclerosis / complications Cardiovascular Diseases / complications, drug therapy* Erectile Dysfunction / drug therapy*, etiology, physiopathology Humans Lower Extremity / blood supply Male Middle Aged Physical Examination Piperazines / therapeutic use* Purines / therapeutic use Regional Blood Flow / physiology Retrospective Studies Risk Factors Sulfones / therapeutic use* Treatment Outcome Vasodilator Agents / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Piperazines; 0/Purines; 0/Sulfones; 0/Vasodilator Agents; 139755-83-2/sildenafil |
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