Document Detail


Efficacy of leucocyte filters during transfusions in preventing the development of anti-HLA antibodies.
MedLine Citation:
PMID:  10773929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The study was planned to investigate the effectiveness of using leucocyte filters in neonates during exchange and erythrocyte transfusion in preventing the development of anti-HLA antibodies. Twenty-four newborn infants who were admitted to the Neonatology Unit and received either exchange or at least two erythrocyte transfusions were recruited. The study group comprised of 12 infants on whom leucocyte filters were used during transfusions. Control group included the remaining 12 infants who were transfused without using a leucocyte filter. Anti-HLA antibodies in the serum samples were studied using modified Amos technique. Presence of anti-HLA antibodies in post-transfusion sera was detected in 3 (25%) of 12 infants in the study (filter) group, while in 10 (83.33%) of 12 infants in the control (no-filter) group. The difference between two groups was statistically significant (p < 0.05). The study demonstrated that term and preterm neonates were capable of developing anti-HLA antibodies following exchange and erythrocyte transfusions, and use of leucocyte filters could efficiently prevent the formation of anti-HLA antibodies.
Authors:
S Kurul; H Ozkan; O Anal; N Akkoç; G Irken
Related Documents :
18245939 - Polycythemia in the newborn.
6351009 - Transfusion-acquired plasmodium malariae infection in two premature infants.
15275989 - Differential diagnosis and management of polycythemia.
21540319 - Utility of the national death index in ascertaining mortality in acquired immunodeficie...
15934899 - Erythropoietin: an update on the therapeutic use in newborn infants and children.
10817399 - Impact of blood sampling in very preterm infants.
1485159 - Fetal growth, preterm birth and infant mortality in relation to work with video display...
8028819 - Iron deficiency and infant development.
21306689 - Prevalence and clinical features of congenital melanocytic nevi in 1,000 spanish newborns.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pediatrics     Volume:  65     ISSN:  0019-5456     ISO Abbreviation:  Indian J Pediatr     Publication Date:    1998 Sep-Oct
Date Detail:
Created Date:  2000-05-09     Completed Date:  2000-05-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417442     Medline TA:  Indian J Pediatr     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  729-34     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Blood Group Incompatibility / prevention & control*
Erythrocyte Transfusion*
Exchange Transfusion, Whole Blood*
Female
Gestational Age
HLA Antigens / blood*
Humans
Infant, Newborn
Isoantibodies / blood*
Leukocytes / immunology*
Male
Risk Factors
Chemical
Reg. No./Substance:
0/HLA Antigens; 0/Isoantibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Viral infections in newborns through exchange transfusion.
Next Document:  Dengue virus infection among children with undifferentiated fever in Karachi.