Document Detail

Efficacy of leucocyte filters during transfusions in preventing the development of anti-HLA antibodies.
MedLine Citation:
PMID:  10773929     Owner:  NLM     Status:  MEDLINE    
The study was planned to investigate the effectiveness of using leucocyte filters in neonates during exchange and erythrocyte transfusion in preventing the development of anti-HLA antibodies. Twenty-four newborn infants who were admitted to the Neonatology Unit and received either exchange or at least two erythrocyte transfusions were recruited. The study group comprised of 12 infants on whom leucocyte filters were used during transfusions. Control group included the remaining 12 infants who were transfused without using a leucocyte filter. Anti-HLA antibodies in the serum samples were studied using modified Amos technique. Presence of anti-HLA antibodies in post-transfusion sera was detected in 3 (25%) of 12 infants in the study (filter) group, while in 10 (83.33%) of 12 infants in the control (no-filter) group. The difference between two groups was statistically significant (p < 0.05). The study demonstrated that term and preterm neonates were capable of developing anti-HLA antibodies following exchange and erythrocyte transfusions, and use of leucocyte filters could efficiently prevent the formation of anti-HLA antibodies.
S Kurul; H Ozkan; O Anal; N Akkoç; G Irken
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pediatrics     Volume:  65     ISSN:  0019-5456     ISO Abbreviation:  Indian J Pediatr     Publication Date:    1998 Sep-Oct
Date Detail:
Created Date:  2000-05-09     Completed Date:  2000-05-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417442     Medline TA:  Indian J Pediatr     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  729-34     Citation Subset:  IM    
Department of Pediatrics, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey.
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MeSH Terms
Blood Group Incompatibility / prevention & control*
Erythrocyte Transfusion*
Exchange Transfusion, Whole Blood*
Gestational Age
HLA Antigens / blood*
Infant, Newborn
Isoantibodies / blood*
Leukocytes / immunology*
Risk Factors
Reg. No./Substance:
0/HLA Antigens; 0/Isoantibodies

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