Document Detail


Efficacy of laryngeal botulinum toxin injection: comparison of two techniques.
MedLine Citation:
PMID:  22024846     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES/HYPOTHESIS: It is hypothesized that there is no difference in the effectiveness of botulinum toxin (BTX) injection between electromyography (EMG)-guided and non-EMG guided "point-touch" techniques in the treatment of adductor spasmodic dysphonia.
STUDY DESIGN: Retrospective chart review.
METHODS: Patients selected for evaluation underwent sequential treatment by one or both of the senior authors using two different injection techniques with similar BTX dilution and preparation. Data gathered included dose injected, injection effect, and presence and duration of breathiness and dysphagia after injection. Statistical analysis was performed used a generalized estimating equations model.
RESULTS: A total of 417 injections in 64 patients were analyzed. There was no difference in the rate of successful injections between the EMG-guidance group and the non-EMG guidance group (94.4% and 93.2%, respectively; P = .7).
CONCLUSIONS: This unique study demonstrates that efficacy of BTX does not necessarily depend on the method of injection used. In experienced hands, excellent clinical results can be achieved with either EMG-guided or non-EMG guided injection techniques.
Authors:
Susan L Fulmer; Albert L Merati; Joel H Blumin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2011-08-16
Journal Detail:
Title:  The Laryngoscope     Volume:  121     ISSN:  1531-4995     ISO Abbreviation:  Laryngoscope     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-10-25     Completed Date:  2011-12-07     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1924-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 The American Laryngological, Rhinological, and Otological Society, Inc.
Affiliation:
Division of Laryngology and Professional Voice, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
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MeSH Terms
Descriptor/Qualifier:
Botulinum Toxins, Type A / administration & dosage*
Electromyography
Female
Humans
Injections / methods*
Male
Middle Aged
Neuromuscular Agents / administration & dosage*
Retrospective Studies
Treatment Outcome
Voice Disorders / drug therapy*
Grant Support
ID/Acronym/Agency:
1UL1RR031973/RR/NCRR NIH HHS; UL1 RR031973-03/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Neuromuscular Agents; EC 3.4.24.69/Botulinum Toxins, Type A
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