Document Detail

Efficacy of laparoscopic radiofrequency ablation for hepatocellular carcinoma compared to percutaneous radiofrequency ablation with artificial ascites.
MedLine Citation:
PMID:  19691779     Owner:  NLM     Status:  MEDLINE    
AIM: Hepatocellular carcinoma (HCC) nodules close to the liver surface exhibit high recurrence compared to those in distal parts of the liver. Moreover, when nodules remain adjacent to the gastrointestinal tract or gallbladder, severe complications such as perforation of those organs may occur due to invasive therapy. Percutaneous radiofrequency ablation (PRFA) with artificial ascites or laparoscopic radiofrequency ablation (LRFA) are used to treat these patients to avoid complications. The purpose of the present study was to assess the efficacy and safety of these two methods. METHODS: Subjects comprised 74 patients (48 men, 26 women; mean age, 68.5 +/- 8.0 years; range, 46-89 years) with 86 HCC nodules. PRFA with artificial ascites was carried out for 37 patients (44 nodules) and LRFA was used for 37 patients (42 nodules). Clinical profiles were compared between groups. RESULTS: No significant differences in clinical profiles were found between patients treated by PRFA or LRFA. Mean number of treatments was significantly lower for LRFA (1.0 +/- 0.0) than for PRFA (2.1 +/- 1.0, P < 0.001). Mean number of PRFA treatments was 2.2 +/- 1.0 in patients with HCC nodules >2 cm in diameter, whereas all tumors were completely ablated with only one session of LRFA. The safety margin was significantly wider for LRFA than for PRFA. CONCLUSION: LRFA is a better treatment option for ablation of HCC nodules >2.0 cm in diameter.
Masashi Hirooka; Yoshiyasu Kisaka; Takahide Uehara; Kiyotaka Ishida; Teru Kumagi; Yuji Watanabe; Masanori Abe; Bunzo Matsuura; Yoichi Hiasa; Morikazu Onji
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society     Volume:  21     ISSN:  1443-1661     ISO Abbreviation:  Dig Endosc     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-08-20     Completed Date:  2009-11-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9101419     Medline TA:  Dig Endosc     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  82-6     Citation Subset:  IM    
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
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MeSH Terms
Aged, 80 and over
Carcinoma, Hepatocellular / therapy*
Catheter Ablation / methods*
Liver Neoplasms / therapy*
Middle Aged
Retrospective Studies
Treatment Outcome

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