Document Detail


Efficacy of lactobionate-enriched cardioplegic solution in preserving compliance of cold-stored heart transplants.
MedLine Citation:
PMID:  8312306     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardioplegic solutions of the extracellular type are commonly used as storage media for heart transplants. Because this type of formulation was not originally designed for preventing hypothermically induced edema, we assessed the effects of supplementing a standard, extracellular-like cardioplegic solution with the high molecular weight impermeant lactobionate on water content and postischemic compliance of isolated rat hearts. In one series of experiments, hearts were immersed in either a standard cardioplegic solution of the extracellular type or in the same solution supplemented with lactobionate (80 mmol/L). Hearts were then processed for measurements of water content after 4 hours, 6 hours, and 8 hours of storage at 4 degrees C. In a second series of experiments, hearts were stored in the same solutions for 4 hours and 8 hours and subsequently reperfused for 1 hour on a Langendorff column, at which time left ventricular pressure-volume curves were constructed and compared with those obtained during the preischemic perfusion. Lactobionate-treated hearts gained significantly less water than controls after 4 hours and 6 hours of storage, but the difference was no longer significant at the 8-hour time point. In contrast, the treated group yielded a significantly better recovery of compliance after both 4 hours and 8 hours of storage, suggesting that lactobionate might exert protective effects in addition to those caused by its impermeant properties, possibly involving calcium chelation and subsequent limitation of calcium-dependent contracture. Extracellular-type cardioplegic solutions are attractive because a single solution can be used during all phases of the transplantation procedure.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
P Menasché; B Hricak; F Pradier; S L Cheav; C Grousset; C Mouas; G Albérici; G Bloch; A Piwnica
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  12     ISSN:  1053-2498     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:    1993 Nov-Dec
Date Detail:
Created Date:  1994-03-23     Completed Date:  1994-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1053-61     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Surgery, Hôpital Lariboisière, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardioplegic Solutions*
Compliance
Coronary Circulation / drug effects
Disaccharides / pharmacology*
Heart / physiology*
Heart Transplantation*
Male
Myocardial Contraction
Myocardial Reperfusion
Organ Preservation*
Rats
Rats, Sprague-Dawley
Ventricular Function, Left / drug effects
Ventricular Pressure / drug effects
Chemical
Reg. No./Substance:
0/Cardioplegic Solutions; 0/Disaccharides; 96-82-2/lactobionic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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