Document Detail


Efficacy of iopanoic acid for treatment of spontaneous hyperthyroidism in cats.
MedLine Citation:
PMID:  21515081     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Iopanoic acid is an iodine containing oral cholecystographic agent that has been used to treat hyperthyroidism in humans and has recently been evaluated in an experimental model of feline hyperthyroidism. The aim of this study was to evaluate the efficacy of iopanoic acid in cats with spontaneous hyperthyroidism. Eleven cats were included in the study. Eight were treated initially with 50mg orally q 12h and three were treated with 100mg orally q 12h. Prior to treatment (baseline) and at 2, 4, and 12 weeks of treatment, owner questionnaires, physical exams, complete blood count, biochemistry analyses, and T(3) and T(4) concentrations were evaluated. The mean serum T(3) concentration decreased with treatment at all time periods compared to baseline. Mean T(4) concentrations were increased at weeks 4 and 12 compared to baseline. Five cats had a partial response during the initial 4 weeks of therapy, but the effects were transient and no significant improvements in clinical signs or physical exam findings were noted at any time period. Results suggest that iopanoic acid may be beneficial for acute management of thyrotoxicosis in some cats, but is not suitable for long-term management.
Authors:
Alexander E Gallagher; David L Panciera
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-04-22
Journal Detail:
Title:  Journal of feline medicine and surgery     Volume:  13     ISSN:  1532-2750     ISO Abbreviation:  J. Feline Med. Surg.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-23     Completed Date:  2011-08-08     Revised Date:  2011-09-22    
Medline Journal Info:
Nlm Unique ID:  100897329     Medline TA:  J Feline Med Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  441-7     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ltd on behalf of ISFM and AAFP.
Affiliation:
Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA. gallaghera@ufl.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Antithyroid Agents / therapeutic use*
Cat Diseases / blood,  drug therapy*
Cats
Dose-Response Relationship, Drug
Female
Hyperthyroidism / blood,  drug therapy,  veterinary*
Iopanoic Acid / therapeutic use*
Male
Thyroxine / blood
Time Factors
Treatment Outcome
Triiodothyronine / blood
Chemical
Reg. No./Substance:
0/Antithyroid Agents; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 96-83-3/Iopanoic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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