Document Detail


Efficacy of intravenous immunoglobulin treatment in refractory uveitis.
MedLine Citation:
PMID:  17162608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To assess the efficacy of intravenous immunoglobulin (IVIg) therapy in patients with severe uveitis otherwise unresponsive to conventional immunomodulatory agents. METHODS: Data on five consecutive patients treated with IVIg and followed to the present time by one of the authors (CSF) were reviewed. All patients had severe and recalcitrant uveitis of diverse etiologies. Main outcome measures were control of intraocular inflammation, steroid-sparing effect, visual acuity, and side effects. RESULTS: The duration of IVIg therapy was 3 to 36 months (mean, 16.8 months). Treatment was effective in controlling the intraocular inflammation in 3 of 5 patients. One of those patients required maintenance of systemic steroids at a dose of 10 mg per day. Visual acuity has stabilized or improved in these three patients. No immediate or long-term side effect was observed in any of the patients. CONCLUSIONS: Intravenous immunoglobulin therapy was an effective therapeutic modality in the treatment of three of five patients with severe uveitis that was unresponsive to conventional immunomodulatory agent(s). No adverse events were observed.
Authors:
Sumru Onal; C Stephen Foster; A Razzaque Ahmed
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ocular immunology and inflammation     Volume:  14     ISSN:  0927-3948     ISO Abbreviation:  Ocul. Immunol. Inflamm.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312169     Medline TA:  Ocul Immunol Inflamm     Country:  England    
Other Details:
Languages:  eng     Pagination:  367-74     Citation Subset:  IM    
Affiliation:
School of Medicine, Department of Ophthalmology, Marmara University, Istanbul, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Drug Resistance
Female
Follow-Up Studies
Glucocorticoids / therapeutic use
Humans
Immunoglobulins, Intravenous / therapeutic use*
Immunologic Factors / therapeutic use*
Male
Uveitis, Anterior / drug therapy*,  pathology
Visual Acuity
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Immunoglobulins, Intravenous; 0/Immunologic Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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