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Efficacy of intracoronary administration of a short-acting β-blocker landiolol during reperfusion in pigs.
MedLine Citation:
PMID:  19709770     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Although β-blockers are used to prevent myocardial ischemia/reperfusion injury, the risk of heart failure has limited β-blocker therapy in patients with acute myocardial infarction. This study evaluated efficacy of intracoronary administration of the short-acting β-blocker, landiolol, during reperfusion in pigs with acute myocardial ischemia.
METHODS AND RESULTS: In the non-ischemic model landiolol administered into the left anterior descending coronary artery (LAD) inhibited in a dose-dependent fashion segmental wall thickening (SWT) in the anterior LV wall without altering SWT in the posterior LV wall and without prolonged depression of global LV function except for the highest dose. In the ischemic model with 60min LAD occlusion followed by reperfusion the medium dose landiolol administered into the LAD 1min before and for 10min during reperfusion inhibited initial recovery of SWT in the anterior LV wall but improved SWT in this region and global LV function late after reperfusion. Ultrastructural studies showed inhibition of sub-sarcolemmal bleb formation by treatment with landiolol 10min after reperfusion associated with the inhibition of CK-MB release and the reduction of infarct size. There was no significant difference in CK-MB release and infarct size between landiolol treatment for 10min and 180min during reperfusion.
CONCLUSIONS: Selective and brief intracoronary administration of landiolol during reperfusion enhances myocardial salvage without causing deterioration of global LV function.
Haengnam Park; Hajime Otani; Chihiro Oishi; Mie Fujikawa; Koji Yamashita; Toru Okazaki; Daisuke Sato; Takanao Ueyama; Junji Iwasaka; Yoshihiro Yamamoto; Toshiji Iwasaka
Publication Detail:
Type:  Journal Article     Date:  2009-08-25
Journal Detail:
Title:  International journal of cardiology     Volume:  146     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  347-53     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.
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