| Efficacy of intermediate-dose oral erythromycin on very low birth weight infants with feeding intolerance. | |
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MedLine Citation:
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PMID: 22348492 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Erythromycin is generally used as a prokinetic agent for the treatment of feeding intolerance in preterm infants; however, results from previous studies significantly vary due to different medication dosages, routes of administration, and therapy durations. The effectiveness and safety of intermediate-dose oral erythromycin in very low birth weight (VLBW) infants with feeding intolerance was examined in this study. METHODS: Between November 2007 and August 2009, 45 VLBW infants with feeding intolerance, who were all at least 14 days old, were randomly allocated to a treatment group and administered 5mg/kg oral erythromycin every 6hours for 14 days (n=19). Another set of randomly selected infants was allocated to the control group, which was not administered erythromycin (n=26). RESULTS: The number of days required to achieve full enteral feeding (36.5±7.4 vs. 54.7±23.3 days, respectively; p=0.01), the duration of parenteral nutrition (p<0.05), and the time required to achieve a body weight ≥2500g (p<0.05) were significantly shorter in the erythromycin group compared with the control group. The incidence of parenteral nutrition-associated cholestasis (PNAC) and necrotizing enterocolitis (NEC) ≥ stage II after 14 days of treatment were significantly lower (p<0.05) in the erythromycin group. No significant differences were observed in terms of the incidences of sepsis, bronchopulmonary dysplasia, or retinopathy of prematurity. No adverse effects were associated with erythromycin treatment. CONCLUSIONS: Intermediate-dose oral erythromycin is effective and safe for the treatment of feeding intolerance in VLBW infants. The incidences of PNAC and ≥ stage II NEC were significant lower in the erythromycin group. |
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Authors:
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Yan-Yan Ng; Pen-Hua Su; Jia-Yuh Chen; Yeak-Wun Quek; Jui-Ming Hu; Inn-Chi Lee; Hong-Shen Lee; Hua-Pin Chang |
Publication Detail:
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Type: Journal Article Date: 2012-01-26 |
Journal Detail:
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Title: Pediatrics and neonatology Volume: 53 ISSN: 1875-9572 ISO Abbreviation: Pediatr Neonatol Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101484755 Medline TA: Pediatr Neonatol Country: Singapore |
Other Details:
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Languages: eng Pagination: 34-40 Citation Subset: IM |
Copyright Information:
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Copyright © 2012. Published by Elsevier B.V. |
Affiliation:
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Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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