Document Detail


Efficacy of interferon therapy in elderly patients with chronic hepatitis C.
MedLine Citation:
PMID:  16428887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We assessed the efficacy and safety of interferon (IFN) monotherapy in 84 elderly patients aged > or =65 years with chronic hepatitis C in a retrospective cohort study. METHODS: Twenty-two of the 84 elderly patients were treated with IFN at a dose of 6 million units daily for 6-8 weeks, 18 patients were treated 2-3 times a week for 24 weeks and 44 patients were treated daily for 2-8 weeks and 2-3 times a week for 16-24 weeks. RESULTS: A sustained virological response (SVR) occurred in 35.7% (30/84) of the patients by intention-to-treat analysis. Multivariate analysis showed that patients achieved a significant SVR when: (1) serum HCV-RNA level before IFN therapy was <100 KIU/ml (p < 0.0001) and (2) staging of liver fibrosis was mild (p = 0.040). Eleven (13.1%) patients discontinued the IFN regimen due to adverse events. Regarding factors predicting discontinuation of IFN, univariate analysis showed that patients aged >70 years were prone to drop out of therapy due to adverse events in IFN therapy (p = 0.009). CONCLUSION: Our results suggest that IFN administration is suitable for 65- to 70-year-old patients with chronic hepatitis C without genotype 1b and high virus load.
Authors:
Rikako Koyama; Yasuji Arase; Kenji Ikeda; Fumitaka Suzuki; Yoshiyuki Suzuki; Satoshi Saitoh; Masahiro Kobayashi; Norio Akuta; Takashi Someya; Tetsuya Hosaka; Hitomi Sezaki; Mariko Kobayashi; Hiromitsu Kumada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Intervirology     Volume:  49     ISSN:  0300-5526     ISO Abbreviation:  Intervirology     Publication Date:  2006  
Date Detail:
Created Date:  2006-01-23     Completed Date:  2006-02-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364265     Medline TA:  Intervirology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  121-6     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, and Hepatic Research Unit, Toranomon Hospital, Tokyo, Japan. rikako@pm.highway.ne.jp
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Aged, 80 and over
Antiviral Agents / adverse effects,  therapeutic use*
Female
Genotype
Hepacivirus / genetics
Hepatitis C, Chronic / drug therapy*,  virology
Humans
Interferons / adverse effects,  therapeutic use*
Male
Patient Dropouts
Retrospective Studies
Viral Load
Chemical
Reg. No./Substance:
0/Antiviral Agents; 9008-11-1/Interferons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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