Document Detail


Efficacy of interferon-alpha in the treatment of chronic hepatitis C in dialysis patients: two therapeutic protocols compared.
MedLine Citation:
PMID:  16374034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Data on the efficacy of particular therapeutic protocols of interferon-alpha (IFN-alpha) treatment for chronic hepatitis C in patients on hemodialysis (HD) vary. AIM: To compare the efficacy of two different therapeutic protocols for HD patients. PATIENTS AND METHODS: 15 hepatitis C virus (HCV)-positive patients on chronic HD at two dialysis centers: 8 patients treated with IFN-alpha 3 x 3 MU/week s.c. for 6 months (group A), and 7 patients treated with IFN-alpha 3 x 5 MU/week for 3 months, then 1 x 5 MU/week for another 3 months (group B). End of treatment response (ETR) and sustained virologic response (SVR) were evaluated by HCV-RNA determination. There was no statistically significant difference between the two patient groups according to age, sex, duration of HD and HCV infection. RESULTS: ETR was 87.5% (7/8) in group A and 28.5% (2/7) in group B, being statistically significant (p < 0.05). Although better SVR [50% (4/8) vs. 28.5% (2/7)] and lower drop-out rate [0% (0/8) vs. 28.5% (2/7)] were achieved in group A compared to group B, these differences did not reach statistical significance (p > 0.05). CONCLUSION: Therapy with IFN-alpha 3 x 3 MU/week s.c. for 6 months seems to be more appropriate for treatment of hepatitis C in HD patients, mostly due to better tolerability, i.e. lower drop-out rate. These differences could be attributed to different pharmacokinetic properties of the particular therapy protocol.
Authors:
Ivica Grgurević; Adriana Vince; Mladen Buljevac; Marko Banić; Branka Jeren-Strujić; Petar Kes; Milan Kujundzić; Ninoslav Leko; Ivan Kresimir Lukić; Jasna Slavicek
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study     Date:  2005-12-21
Journal Detail:
Title:  Nephron. Clinical practice     Volume:  103     ISSN:  1660-2110     ISO Abbreviation:  Nephron Clin Pract     Publication Date:  2006  
Date Detail:
Created Date:  2006-04-13     Completed Date:  2006-05-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101159763     Medline TA:  Nephron Clin Pract     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  c8-11     Citation Subset:  IM    
Copyright Information:
2006 S. Karger AG, Basel.
Affiliation:
Department of Gastroenterology and Hepatology, Dubrava University Hospital, Zagreb, Croatia. ivica.grgurevic@zg.htnet.hr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antiviral Agents / administration & dosage*
Clinical Protocols
Female
Hepatitis C, Chronic / drug therapy*
Humans
Interferon-alpha / administration & dosage*
Male
Middle Aged
Renal Dialysis*
Retrospective Studies
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Interferon-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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