| Efficacy of interferon-alpha in the treatment of chronic hepatitis C in dialysis patients: two therapeutic protocols compared. | |
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MedLine Citation:
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PMID: 16374034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Data on the efficacy of particular therapeutic protocols of interferon-alpha (IFN-alpha) treatment for chronic hepatitis C in patients on hemodialysis (HD) vary. AIM: To compare the efficacy of two different therapeutic protocols for HD patients. PATIENTS AND METHODS: 15 hepatitis C virus (HCV)-positive patients on chronic HD at two dialysis centers: 8 patients treated with IFN-alpha 3 x 3 MU/week s.c. for 6 months (group A), and 7 patients treated with IFN-alpha 3 x 5 MU/week for 3 months, then 1 x 5 MU/week for another 3 months (group B). End of treatment response (ETR) and sustained virologic response (SVR) were evaluated by HCV-RNA determination. There was no statistically significant difference between the two patient groups according to age, sex, duration of HD and HCV infection. RESULTS: ETR was 87.5% (7/8) in group A and 28.5% (2/7) in group B, being statistically significant (p < 0.05). Although better SVR [50% (4/8) vs. 28.5% (2/7)] and lower drop-out rate [0% (0/8) vs. 28.5% (2/7)] were achieved in group A compared to group B, these differences did not reach statistical significance (p > 0.05). CONCLUSION: Therapy with IFN-alpha 3 x 3 MU/week s.c. for 6 months seems to be more appropriate for treatment of hepatitis C in HD patients, mostly due to better tolerability, i.e. lower drop-out rate. These differences could be attributed to different pharmacokinetic properties of the particular therapy protocol. |
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Authors:
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Ivica Grgurević; Adriana Vince; Mladen Buljevac; Marko Banić; Branka Jeren-Strujić; Petar Kes; Milan Kujundzić; Ninoslav Leko; Ivan Kresimir Lukić; Jasna Slavicek |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study Date: 2005-12-21 |
Journal Detail:
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Title: Nephron. Clinical practice Volume: 103 ISSN: 1660-2110 ISO Abbreviation: Nephron Clin Pract Publication Date: 2006 |
Date Detail:
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Created Date: 2006-04-13 Completed Date: 2006-05-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101159763 Medline TA: Nephron Clin Pract Country: Switzerland |
Other Details:
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Languages: eng Pagination: c8-11 Citation Subset: IM |
Copyright Information:
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2006 S. Karger AG, Basel. |
Affiliation:
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Department of Gastroenterology and Hepatology, Dubrava University Hospital, Zagreb, Croatia. ivica.grgurevic@zg.htnet.hr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antiviral Agents / administration & dosage* Clinical Protocols Female Hepatitis C, Chronic / drug therapy* Humans Interferon-alpha / administration & dosage* Male Middle Aged Renal Dialysis* Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Interferon-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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